产品名称
17:0-14:1 PS, Avanti Research™ - A Croda Brand LM1304, methanol solution
InChI key
ZBOCVGFQVSWMHT-BPNWTSRKSA-N
SMILES string
[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCCCCCCCCCCC)=O.[NH4+]
assay
>99% (TLC)
form
methanol solution
packaging
pkg of 1 × 1 mL (LM1304-1EA)
manufacturer/tradename
Avanti Research™ - A Croda Brand LM1304
concentration
~10 μg/mL (Refer to C of A for lot specific concentration. )
application(s)
lipidomics
metabolomics
shipped in
dry ice
storage temp.
−20°C
Application
17:0-14:1 PS or 1-heptadecanoyl-2-(9Z-tetradecenoyl)-sn-glycero-3-phospho-L-serine has been used as an internal standard:
- for the detection of lipids by tandem mass spectrometry (MS/MS)
- to determine lipid concentration in human primary myotubes lipid extracts by mass spectrometry (MS) analysis
- for phospholipid quantification by MS
- for lipid extraction by methyl tert-butyl ether (MTBE) method
- for lipid quantification using liquid chromatography (LC)-MS
Biochem/physiol Actions
Phosphatidylserine (PS) is associated with the Akt, protein kinase C (PKC) and Raf-1 signaling. It supports neuronal survival, neurite growth and synaptogenesis.
General description
Phosphatidylserine (PS) is an acidic phospholipid present in human cerebral cortex. It is abundant in the inner leaflet of the plasma membrane in neural tissues.
Packaging
2 mL Amber Glass Sealed Ampule (LM1304-1EA)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
法规信息
危险化学品
此项目有
Hee-Yong Kim et al.
Progress in lipid research, 56, 1-18 (2014-07-06)
Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the inner leaflet of the plasma membrane in neural tissues. PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is
Ursula Loizides-Mangold et al.
Journal of lipid research, 53(8), 1522-1534 (2012-05-26)
Glycosylphosphatidylinositol (GPI) anchor biosynthesis takes place in the endoplasmic reticulum (ER). After protein attachment, the GPI anchor is transported to the Golgi where it undergoes fatty acid remodeling. The ER exit of GPI-anchored proteins is controlled by glycan remodeling and
Laurent Perrin et al.
eLife, 7 (2018-04-17)
Circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes synchronized in vitro. More extensive
Alexander Fauland et al.
Journal of lipid research, 52(12), 2314-2322 (2011-10-01)
This work aims to combine chromatographic retention, high mass resolution and accuracy, MS/MS spectra, and a package for automated identification and quantitation of lipid species in one platform for lipidomic analysis. The instrumental setup elaborated comprises reversed-phase HPLC coupled to
Yakir Guri et al.
Cancer cell, 32(6), 807-823 (2017-12-13)
Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying mechanisms are poorly understood. We describe an mTOR-driven mouse model that displays hepatosteatosis progressing to hepatocellular carcinoma (HCC). Longitudinal proteomic, lipidomics, and metabolomic analyses revealed that hepatic mTORC2 promotes de
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