产品名称
13:0 Lyso LPC, Avanti Research™ - A Croda Brand
InChI
1S/C21H44NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-21(24)27-18-20(23)19-29-30(25,26)28-17-16-22(2,3)4/h20,23H,5-19H2,1-4H3/p+1/t20-/m1/s1
InChI key
WNRCJJWBAXNAPE-HXUWFJFHSA-O
SMILES string
O[C@](COP(O)(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCCCCC)=O
assay
>99% (TLC)
form
methanol solution
packaging
pkg of 1 × 1 mL (LM1600-1EA)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
~10 μg/mL (Refer to C of A for lot specific concentration. )
application(s)
lipidomics
metabolomics
shipped in
dry ice
storage temp.
−20°C
Application
13：0溶血LPC或1-十三烷酰基-sn-甘油-3-磷酸胆碱已被用作内标：
- 从脑组织中提取脂质
- 使用改良的Bligh和Dyer方案从巨噬细胞中提取脂质
- 溶血磷脂的液相色谱/质谱分析
Biochem/physiol Actions
已知溶血磷脂酰胆碱（LPC）是一种生物活性分子，与动脉粥样硬化的进展有关，并发现病变/斑块中LPC的高浓度。在表明心血管疾病的氧化损伤的低密度脂蛋白（oxLDL）中也发现较高水平的LPC。LPC参与多种生物过程，例如血管再生，发育和髓磷脂形成。还已知它与神经元疾病和癌症有关。
General description
溶血磷脂酰胆碱（LPC）是一种极性脂质，位于氧化脂蛋白的细胞膜上。
Packaging
2mL琥珀色玻璃密封安瓿（LM1600-1EA）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
法规信息
危险化学品
此项目有
Jaewoo Choi et al.
Chemical research in toxicology, 24(1), 111-118 (2010-10-27)
Elevated levels of lysophosphatidylcholine (lysoPC), present in oxidatively damaged low-density lipoprotein (oxLDL), are implicated in cardiovascular complications. LysoPC is generated by free radical-catalyzed oxidation of polyunsaturated PCs to oxidatively truncated phosphophatidylcholines (oxPCs). It is known that oxPCs are especially susceptible
Kasey C Vickers et al.
Atherosclerosis, 211(1), 122-129 (2010-05-11)
Calcifying vascular cells in human atherosclerotic plaques actively contribute to ectopic vascular mineralization. Lyso-phosphatidylcholine (LPC), a product of oxidized phosphatidylcholine hydrolysis, is found at concentrations of 1-12 microg/g tissue throughout the atheroma. The objective of this study was to determine
Matthew W Granger et al.
Journal of neurochemistry, 149(4), 499-517 (2018-07-25)
Changes in glycerophosphocholine metabolism are observed in Alzheimer's disease; however, it is not known whether these metabolic disruptions are linked to cognitive decline. Here, using unbiased lipidomic approaches and direct biochemical assessments, we profiled Land's cycle lipid remodeling in the
Shayne A Snider et al.
The Journal of biological chemistry, 293(29), 11600-11611 (2018-06-09)
Choline is an essential nutrient that is required for synthesis of the main eukaryote phospholipid, phosphatidylcholine. Macrophages are innate immune cells that survey and respond to danger and damage signals. Although it is well-known that energy metabolism can dictate macrophage
Judith Simcox et al.
Cell metabolism, 26(3), 509-522 (2017-09-07)
Cold-induced thermogenesis is an energy-demanding process that protects endotherms against a reduction in ambient temperature. Using non-targeted liquid chromatography-mass spectrometry-based lipidomics, we identified elevated levels of plasma acylcarnitines in response to the cold. We found that the liver undergoes a
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