LM2001
Avanti
Sphinganine (d17:0)
Avanti Research™ - A Croda Brand
别名:
(2S,3R)-2-aminoheptadecane-1,3-diol, C17 Sphinganine
Product Name
Sphinganine (d17:0), heptadecasphinganine, ethanol solution
表单
ethanol solution
包装
pkg of 1 × 1 mL (LM2001-1EA)
制造商/商品名称
Avanti Research™ - A Croda Brand LM2001
浓度
~10 μg/mL (Refer to C of A for lot specific concentration.)
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCC
InChI
1S/C17H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(20)16(18)15-19/h16-17,19-20H,2-15,18H2,1H3/t16-,17+/m0/s1
InChI key
KFQUQCFJDMSIJF-DLBZAZTESA-N
一般描述
Sphinganine, also known as dihydrosphingosine is a sphingoid base precursor of ceramide.
应用
Sphinganine (d17:0) has been used as a constituent of the internal standard mixture in mass spectrometry.
生化/生理作用
Sphinganine (SPA) is involved in sphingolipid biosynthesis pathway. It is free from the double bond. SPA has an ability to inhibit the activity of protein kinase c. SPA accumulation enables fumonisin B1 to stimulate apoptosis.
Sphinganine plays a vital role in cell regulation, cell growth modulation and signal transmission, functioning as an inhibitor of protein kinase C. It inhibits the low-density lipoprotein-induced esterification of cholesterol by the blockage of post-lysosomal cholesterol transport. Sphinganine is useful as a biomarker for studying microbial diversity.
包装
2 mL Amber Glass Sealed Ampule (LM2001-1EA)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
55.4 °F - closed cup
闪点(°C)
13.0 °C - closed cup
法规信息
危险化学品
A stereoselective synthesis of dihydrosphingosine
Fernandes RA and Kumar P
European Journal of Organic Chemistry, 2000(20), 3447-3449 (2000)
Urinary metabolomic profiling in Zucker diabetic fatty rats with type 2 diabetes mellitus treated with glimepiride, metformin, and their combination
Dong Y, et al.
Molecules (Basel), 21(11), 1446-1446 (2016)
Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase
Enongene EN, et al.
Toxicological Sciences, 67(2), 173-181 (2002)
Quantification of sphingosine and sphinganine from crude lipid extracts by HPLC electrospray ionization tandem mass spectrometry
Lieser B, et al.
Journal of Lipid Research, 44(11), 2209-2216 (2003)
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2
Takabe, et al.
Test, 285(14) (2010)
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