InChI
1S/C30H59NO3/c1-3-5-7-9-11-13-14-15-16-18-19-21-23-25-29(33)28(27-32)31-30(34)26-24-22-20-17-12-10-8-6-4-2/h23,25,28-29,32-33H,3-22,24,26-27H2,1-2H3,(H,31,34)/b25-23+/t28-,29+/m0/s1
InChI key
HXFPPRPLRSPNIB-VARSQMIESA-N
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
assay
>99% (TLC)
form
ethanol solution
packaging
pkg of 1 × 1 mL (LM2212-1EA)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
~10 μg/mL (Refer to C of A for lot specific concentration.)
application(s)
lipidomics
metabolomics
shipped in
dry ice
storage temp.
−20°C
General description
Ceramide is a sphingolipid with long acyl chain attached to a fatty. It is synthesized in the endoplasmic reticulum by ceramide synthase.
Biochem/physiol Actions
Ceramide functions as a secondary messenger to initiate apoptosis. It also regulates physiological processes and is accountable for the epidermal permeability barrier in eukaryotic membranes.
Packaging
2 mL Amber Glass Sealed Ampule (LM2212-1EA)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
55.4 °F - closed cup
flash_point_c
13.0 °C - closed cup
法规信息
危险化学品
此项目有
The enigma of ceramide synthase regulation in mammalian cells
Wegner MS, et al.
Progress in Lipid Research, 63, 93-119 (2016)
Radiation and ceramide-induced apoptosis
Kolesnick R and Fuks Z
Oncogene, 22(37), 5897-5897 (2003)
Nesli-Ece Sen et al.
International journal of molecular sciences, 20(23) (2019-11-27)
Ataxin-2 (human gene symbol ATXN2) acts during stress responses, modulating mRNA translation and nutrient metabolism. Ataxin-2 knockout mice exhibit progressive obesity, dyslipidemia, and insulin resistance. Conversely, the progressive ATXN2 gain of function due to the fact of polyglutamine (polyQ) expansions
Mammalian Ceramide Synthases
Levy M and Futerman AH
Febs Letters, 62(5), 347-356 (2010)
Guang-Yi Dai et al.
The Journal of biological chemistry, 295(3), 717-728 (2019-12-11)
Cellular membranes contain many lipids, some of which, such as sphingolipids, have important structural and signaling functions. The common sphingolipid glucosylceramide (GlcCer) is present in plants, fungi, and animals. As a major plant sphingolipid, GlcCer is involved in the formation
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