grade
certified reference material
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
25 μg/mL in methanol (each analyte)
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
application(s)
pharmaceutical (small molecule)
format
multi-component solution
storage temp.
−20°C
General description
Acetaminophen is formed as a metabolic product of phenacetin and is a well-known drug used in the treatment of pain and fever due to its effective central analgesic and antipyretic properties. It is also the only analgesic drug that is non-opioid and available in the oral, rectal, and intravenous formulation forms. It has been posited to inhibit the synthesis of prostaglandins and exhibit a mode of action similar to nonsteroidal anti-inflammatory drugs (NSAIDs).
Application
Acetaminophen Impurity Mixture solution may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
分析物
说明
Acetaminophen Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material
Acetaminophen Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material
Acetaminophen Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material
Acetaminophen Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material
Acetaminophen, Pharmaceutical Secondary Standard; Certified Reference Material
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Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
法规信息
监管及禁止进口产品
此项目有
Intravenous paracetamol (acetaminophen)
Duggan ST and Scott LJ
Drugs, 69(1), 101- 113 (2009)
Acetaminophen poisoning and toxicity
Rumack BH and Matthew H
Pediatrics, 55(6), 871- 876 (1975)
Central analgesic effect of acetaminophen but not of aspirin
Piletta P, et al.
Clinical Pharmacology and Therapeutics, 49(4), 350- 354 (1991)
Paracetamol (Acetaminophen): mechanisms of action
Anderson BJ
Pediatric Anesthesia, 18(10), 915- 921 (2008)
Acetaminophen-induced hepatotoxicity
James LP, et al.
Drug Metabolism and Disposition, 31(12), 1499- 1506 (2003)
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