E-006
EDDP perchlorate
ampule of 10 mg, certified reference material, Cerilliant®
别名:
2-亚乙基-1,5-二甲基-3,3-二苯基吡咯烷高氯酸酯
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关于此项目
经验公式（希尔记法）:
C20H23N · HClO4
化学文摘社编号:
分子量:
377.86
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
certified reference material
质量水平
表单
solid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 10 mg
制造商/商品名称
Cerilliant®
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
包装形式
neat
储存温度
−20°C
一般描述
A Certified Reference Material of the major urinary metabolite of methadone. Methadone, sold under various trade names such as Symoron, Amidone or Methadose®, is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. Suitable uses for this reference standard include as starting material in preparation of calibrators and controls for LC/MS or GC/MS methods in methadone testing for applications in clinical toxicology or forensic analysis.
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Methadose is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Cristiana Gambelunghe et al.
Annals of clinical and laboratory science, 43(1), 22-30 (2013-03-07)
It may be advantageous to use sweat, rather than blood or urine, to monitor individuals' drug exposure for the purposes of drug treatment programs, employment initiatives, and forensic investigations. Forty-eight patients receiving methadone at the Public Service for the Treatment
Ricarda Jantos et al.
Forensic science international, 226(1-3), 254-260 (2013-02-21)
Body fluids and tissues in 16 methadone (MTD)-associated fatalities were investigated to find out whether analysis of MTD and its metabolite 2-ethylidine-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) following enantioselective separation of both compounds may assist in the interpretation of MTD findings. Individual case histories
Karen Marie Dollerup Holm et al.
Journal of analytical toxicology, 36(7), 487-496 (2012-07-11)
We developed a method based on liquid chromatography coupled with tandem mass spectrometry to quantify individual enantiomers of methadone and its primary metabolite, R/S-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP), in postmortem blood and brain tissue. Samples were prepared with a Tecan Evo robotic system.
Maksymilian Kulza et al.
Przeglad lekarski, 67(10), 925-928 (2010-01-01)
Methadone maintenance therapy is one of the most popular treatments for opiate addiction. The easiest and the most reliable way to monitor the accuracy of the therapy is determination of methadone and its metabolites in biological material. The aim of
Mei-Han Huang et al.
Toxicology, 280(1-2), 1-9 (2010-11-26)
Methadone (Mtd) is a widely used opioid drug associated with the side effect of hyperprolactinemia. The mechanism of how Mtd induces prolactin secretion remains unclear. The effects of Mtd and its two main metabolites (EDDP: (±)-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium percholarate and EMDP: 2-ethyl-5-methyl-3,3-dipnehyl-1-pyrroline)
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