F-052
呋塞米杂质混合物 溶液
5 μg/mL (50:50 Acetonitrile:Water, each analyte), certified reference material, ampule of 1 mL, Cerilliant®
grade
certified reference material
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
composition
2-Chloro-4-furfurylamino-5-sulfamoylbenzoic acid, 5 μg/mL , 4-Chloro-5-sulfamoylanthranilic acid (Furosemide RCB), 5 μg/mL , Furosemide, 5 μg/mL
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
5 μg/mL (50:50 Acetonitrile:Water, each analyte)
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
application(s)
pharmaceutical (small molecule)
format
multi-component solution
storage temp.
−20°C
General description
Furosemide is a powerful diuretic agent with the ascending limb of Henle′s loop of nephron as its primary site of action. It works by preventing the reabsorption of sodium and increasing the secretion of renal vasodilatory prostaglandin E. In combination with nitrates, it is used as the standard treatment for pulmonary edema caused by acute heart failure.
Application
Furosemide Impurity Mixture solution may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
分析物
说明
Furosemide, Pharmaceutical Secondary Standard; Certified Reference Material
Furosemide Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material
Furosemide Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
50.0 °F
flash_point_c
10 °C
法规信息
危险化学品
此项目有
Lack of renoprotective effects of dopamine and furosemide during cardiac surgery
Lassnigg A, et al.
Journal of the American Society of Nephrology, 11(1), 97-104 (2000)
Furosemide effect on isolated perfused tubules
Burg M, et al.
The American Journal of Physiology, 225(1), 119-124 (1973)
Randomised trial of high-dose isosorbide dinitrate plus low-dose furosemide versus high-dose furosemide plus low-dose isosorbide dinitrate in severe pulmonary oedema
Cotter G, et al.
Lancet, 351(9100), 389-393 (1998)
Furosemide
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 41(3), 2006-2006 (2018)
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