M-095
褪黑素标准液 溶液
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
InChI key
DRLFMBDRBRZALE-UHFFFAOYSA-N
InChI
1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
SMILES string
COc1ccc2[nH]cc(CCNC(C)=O)c2c1
grade
certified reference material
Quality Level
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
General description
褪黑激素是一种天然激素，具有多种作用，尤其是影响昼夜节律。褪黑激素可作为助眠剂出售，在某些国家/地区可作为膳食补充剂出售。该认证的加标溶液适用于通过 LC-MS/MS 或 GC/MS 在褪黑激素测试应用中。
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
法规信息
危险化学品
此项目有
Sylvie Tordjman et al.
International journal of molecular sciences, 14(10), 20508-20542 (2013-10-17)
Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin
Monique K LeBourgeois et al.
Journal of biological rhythms, 28(5), 322-331 (2013-10-18)
Circadian phase and its relation to sleep are increasingly recognized as fundamental factors influencing human physiology and behavior. Dim light melatonin onset (DLMO) is a reliable marker of the timing of the circadian clock, which has been used in experimental
Darío Acuña-Castroviejo et al.
Cellular and molecular life sciences : CMLS, 71(16), 2997-3025 (2014-02-21)
Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is considered an indoleamine from a biochemical point of view because the melatonin molecule contains a substituted indolic ring with an amino group. The circadian production of melatonin by the pineal
P Boyce et al.
Acta psychiatrica Scandinavica. Supplementum, (444)(444), 16-23 (2013-08-09)
Disturbances in circadian rhythms have been associated with major depression and may be an underlying mechanism for the disorder. Resynchronisation of circadian rhythms may provide a new approach to treatment, especially by manipulating melatonin secretion. Melatonin is secreted at night
Jerry Vriend et al.
Life sciences, 115(1-2), 8-14 (2014-09-16)
Proteasome inhibitors and melatonin are both intimately involved in the regulation of major signal transduction proteins including p53, cyclin p27, transcription factor NF-κB, apoptotic factors Bax and Bim, caspase 3, caspase 9, anti-apoptotic factor Bcl-2, TRAIL, NRF2 and transcription factor
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