N-076
甲基亚硝胺基吡啶基丁酮(NNK)标准液 CRM 溶液
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
别名:
4-(甲基亚硝氨基)-1-(3-吡啶基)-1-丁酮, 4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁酮, NNK
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关于此项目
经验公式（希尔记法）:
C10H13N3O2
化学文摘社编号:
分子量:
207.23
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
certified reference material
质量水平
表单
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
forensics and toxicology
包装形式
single component solution
储存温度
−20°C
SMILES字符串
CN(CCCC(=O)c1cccnc1)N=O
InChI
1S/C10H13N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8H,3,5,7H2,1H3
InChI key
FLAQQSHRLBFIEZ-UHFFFAOYSA-N
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一般描述
该认证加标溶液®适用于LC-MS/MS或GC/MS法尼古丁检测、环境监测，或者尼古丁生物标记物的临床和诊断检测。NNK又称为尼古丁源亚硝胺酮，是一种强效致癌物，也是香烟烟雾暴露的生物标志物。NNK在烟草炮制过程中产生，常见于各种烟草产品中，包括嚼烟、鼻烟、香烟和雪茄。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
危险化学品
Lucie Skarydova et al.
Drug metabolism letters, 6(3), 174-181 (2013-01-22)
Tobacco smoking is the most widely known cause of human cancer-related death worldwide. NNK is one of the proved human carcinogens contributing to the development of several types of cancer. The carcinogenic effect of NNK depends on the metabolic pathway.
Chi-Jung Chung et al.
Toxicology letters, 216(1), 16-22 (2012-11-13)
Gene polymorphisms of the 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes-cytochrome P450 (CYP) monooxygenase 2A13 (CYP2A13) and UDP-glucuronosyltransferases (UGT)-2B7 could contribute to the levels of NNK-related metabolites in urine, thereby increasing the susceptibility to urothelial carcinoma (UC). Therefore, our study aimed to evaluate
Shioko Kimura et al.
Molecular cancer, 11, 90-90 (2012-12-14)
The CCAAT/enhancer binding proteins (C/EBPs) play important roles in carcinogenesis of many tumors including the lung. Since multiple C/EBPs are expressed in lung, the combinatorial expression of these C/EBPs on lung carcinogenesis is not known. A transgenic mouse line expressing
Jing Wang et al.
Asian Pacific journal of cancer prevention : APJCP, 13(5), 2207-2212 (2012-08-21)
Overexpression of DNA methyltransferase 1 (DNMT1) has been detected in many cancers. Tobacco exposure is known to induce genetic and epigenetic changes in the pathogenesis of malignancy. 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK) is an important carcinogen present in tobacco smoke; however the
William Gordon et al.
European journal of cancer (Oxford, England : 1990), 49(3), 725-733 (2012-09-27)
The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), an important carcinogen found in tobacco products, causes lung cancer in genetically susceptible animals. In addition to mutations of the K-Ras gene, NNK has non-mutagenic effects that include alterations in gene expression and immunomodulation in the
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