SMC^® Human IgE High Sensitivity Immunoassay Kit

Immunoglobulin E (IgE) antibodies are crucial for the body’s defense against allergens and parasites, serving as a key indicator of allergic sensitization. When an individual encounters an allergen, the immune system generates specific IgE antibodies that bind to high-affinity receptors on mast cells and basophils. Upon subsequent exposure to the same allergen, this binding triggers the release of histamines and other inflammatory mediators. Therapeutic proteins and vaccines can also provoke an immune response characterized by the production of IgE antibodies. Measuring the immunogenicity of these substances is vital for evaluating their safety and efficacy. Elevated IgE levels can signal an increased risk of hypersensitivity reactions, complicating treatment outcomes. Understanding IgE immunogenicity is essential for developing new drugs and vaccines, as it helps identify potential reactions and informs the design of therapies aimed at minimizing adverse effects.

Inflammatory Disease / Immune Response / Immunoglobulin & Immunology

96 well assay

• Sensitivity: LLOQ 31,000 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 10,000-7,500,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 88% Plasma: 104%
• Recovery: Serum: 86% Plasma: 89%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

SMC is a registered trademark of Singulex

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.