03-0204-00
SMC® Human IgM High Sensitivity Immunoassay Kit
Used for ultrasensitive quantification of Human IgM in human serum and plasma
别名:
IgM ultra-sensitive immunoassay, Immunoglobulin M immunoassay kit, IgM Single Molecule Counting kit, IgM immunoassay kit
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NACRES:
NA.84
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments, for use with SMCxPRO® and Erenna (validated)
Quality Level
product line
SMC®
species reactivity
human
manufacturer/tradename
SMC®
technique(s)
single molecule counting: suitable
input
plasma (K2 EDTA)
serum
UniProt accession no.
compatibility
for use with FemtoQuest™ and SMCxPRO® instruments, for use with SMCxPRO® and Erenna (validated)
shipped in
wet ice
storage temp.
2-8°C
General description
IgM (Immunoglobulin M) is the first antibody produced by the immune system in response to an infection or exposure to an antigen. It plays a critical role in the early stages of immune defense, providing a rapid response to pathogens. IgM is typically present in the bloodstream and is known for its ability to form pentamers, which enhances its capacity to bind to multiple antigens simultaneously and activate the complement system, leading to the destruction of pathogens.
Measuring IgM response is critical to vaccine development and infectious disease management. When a vaccine is administered, the body generates IgM antibodies as part of the initial immune response. Elevated IgM levels can indicate recent infections or acute immune responses, making it a valuable indicator of infection. An understanding of IgM immunogenicity is essential for evaluating vaccine efficacy and the immune response to infectious agents.
IgM also plays a significant role in assessing the safety of therapeutic proteins and other biologics, as it can signal potential hypersensitivity reactions. By studying IgM immunogenicity, researchers can identify risks associated with new treatments and enhance the design of vaccines and therapies to improve their effectiveness and minimize adverse effects.
Measuring IgM response is critical to vaccine development and infectious disease management. When a vaccine is administered, the body generates IgM antibodies as part of the initial immune response. Elevated IgM levels can indicate recent infections or acute immune responses, making it a valuable indicator of infection. An understanding of IgM immunogenicity is essential for evaluating vaccine efficacy and the immune response to infectious agents.
IgM also plays a significant role in assessing the safety of therapeutic proteins and other biologics, as it can signal potential hypersensitivity reactions. By studying IgM immunogenicity, researchers can identify risks associated with new treatments and enhance the design of vaccines and therapies to improve their effectiveness and minimize adverse effects.
Application
Inflammatory Disease / Immune Response / Autoimmune Disease
Biochem/physiol Actions
This assay does not show cross-reactivity against immunoglobulin subclasses IgA, IgD, IdE, IgG1, IgG2, IgG3, or IgG4 from in-house testing
Features and Benefits
- Ultra-Sensitive Measurement: Enables detection of IgM down to fg/mL levels in diluted serum and plasma samples.
- Reliable Data: Enhanced dynamic range with improved signal-to-noise ratio ensures accurate and dependable results.
- Intuitive Assay Workflow: Follow a straightforward protocol to achieve high-sensitivity detection.
- Automated Workflow: Compatible with automated liquid handling systems to reduce manual steps and boosts laboratory productivity.
- Expert Support: Technical assistance is provided by specialized field scientists and technical teams.
Packaging
96 well assay
Analysis Note
- Sensitivity: LLOQ 206,000 fg/mL* (SMCxPRO® Instrument)
- Standard Curve Range: 69,000-5,000,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Linearity: Serum: 100% Plasma: 97%
- Recovery: Serum: 79% Plasma: 79%
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
signalword
Danger
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B
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