03-34-0027
H-Gly-Arg-Gly-Asp-Ser-OH - CAS 96426-21-0 - Calbiochem
别名:
H-Gly-Arg-Gly-Asp-Ser-OH - CAS 96426-21-0 - Calbiochem, GRGDS
InChI
1S/C17H30N8O9/c18-5-11(27)23-8(2-1-3-21-17(19)20)14(31)22-6-12(28)24-9(4-13(29)30)15(32)25-10(7-26)16(33)34/h8-10,26H,1-7,18H2,(H,22,31)(H,23,27)(H,24,28)(H,25,32)(H,29,30)(H,33,34)(H4,19,20,21)/t8-,9-,10-/m0/s1
InChI key
RGNVSYKVCGAEHK-GUBZILKMSA-N
assay
≥97% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white to off-white
solubility
5% acetic acid: 1 mg/mL, water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell binding protein domain. Competitively inhibits direct binding of fibroblasts to fibronectin. In mice it has been shown to prevent bladder tumor cell implantation. Also, reported to inhibit the migration of vascular smooth muscle cells into fibrin gels.
Biochem/physiol Actions
Cell permeable: no
Primary Target
fibroblast binding
fibroblast binding
Product does not compete with ATP.
Reversible: no
Physical form
Supplied as an acetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Kodama, M., et al. 2002. Life Sci.71, 1139.
Hyacinthe, L.M., et al. 1995. Ann. Surg. Oncol.2, 450.
Pierschbacher, M.D., and Ruoslahti, E. 1984. Nature309, 30.
Hyacinthe, L.M., et al. 1995. Ann. Surg. Oncol.2, 450.
Pierschbacher, M.D., and Ruoslahti, E. 1984. Nature309, 30.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
法规信息
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