04-080
抗-BAF250a/ARID1a抗体，克隆PSG3
clone PSG3, Upstate®, from mouse
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
PSG3, monoclonal
Application:
IF, WB
Citations:
19
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
PSG3, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
immunofluorescence: suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ARID1A (8289)
General description
~270 kDa
Immunogen
GST融合蛋白，对应人BAF250a/ARID1a中部419个残基。
Application
抗BAF250a/ARID1A抗体，克隆PSG3是针对BAF250a/ARID1A的抗体，用于WB，ChIP，IC & IHC。
研究子类别
染色质生物学
转录因子
染色质生物学
转录因子
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
BAF250a/ARID1a
Physical form
100 μg蛋白A纯化的小鼠单克隆IgG，溶于100 μL 1X PBS（pH 7.0，0.1%叠氮化物）中。
形式：纯化
蛋白A纯化
Preparation Note
自运送之日起在-20°C下保存2年
Analysis Note
已通过免疫印迹进行常规评估。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.
Chandler, RL; Damrauer, JS; Raab, JR; Schisler, JC; Wilkerson, MD; Didion, JP; Starmer et al.
Nature Communications null
Hiroko Inoue et al.
The Journal of biological chemistry, 277(44), 41674-41685 (2002-08-30)
The mammalian SWI/SNF-related complexes facilitate gene transcription by remodeling chromatin using the energy of ATP hydrolysis. The recruitment of these complexes to promoters remains poorly understood and may involve histone modifications or direct interactions with site-specific transcription factors or other
Zuqin Nie et al.
Molecular and cellular biology, 23(8), 2942-2952 (2003-04-01)
The SWI/SNF family of chromatin-remodeling complexes has been discovered in many species and has been shown to regulate gene expression by assisting transcriptional machinery to gain access to their sites in chromatin. Several complexes of this family have been reported
Essential role of ARID2 protein-containing SWI/SNF complex in tissue-specific gene expression.
Xu, F; Flowers, S; Moran, E
The Journal of Biological Chemistry null
Radhika Mathur et al.
Nature genetics, 49(2), 296-302 (2016-12-13)
Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are collectively mutated in ∼20% of all human cancers. Although ARID1A is the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis is unclear. Here we demonstrate that
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