04-080
抗-BAF250a/ARID1a抗体，克隆PSG3
clone PSG3, Upstate®, from mouse
别名:
Anti-B120, Anti-BAF250, Anti-BAF250a, Anti-BM029, Anti-C1orf4, Anti-CSS2, Anti-ELD, Anti-MRD14, Anti-OSA1, Anti-P270, Anti-SMARCF1, Anti-hELD, Anti-hOSA1
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
PSG3, monoclonal
种属反应性
human
制造商/商品名称
Upstate®
技术
immunofluorescence: suitable
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
unmodified
基因信息
human ... ARID1A (8289)
一般描述
~270 kDa
免疫原
GST融合蛋白，对应人BAF250a/ARID1a中部419个残基。
应用
抗BAF250a/ARID1A抗体，克隆PSG3是针对BAF250a/ARID1A的抗体，用于WB，ChIP，IC & IHC。
研究子类别
染色质生物学
转录因子
染色质生物学
转录因子
研究类别
表观遗传学&核功能
表观遗传学&核功能
生化/生理作用
BAF250a/ARID1a
外形
100 μg蛋白A纯化的小鼠单克隆IgG，溶于100 μL 1X PBS（pH 7.0，0.1%叠氮化物）中。
形式：纯化
蛋白A纯化
制备说明
自运送之日起在-20°C下保存2年
分析说明
已通过免疫印迹进行常规评估。
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.
Chandler, RL; Damrauer, JS; Raab, JR; Schisler, JC; Wilkerson, MD; Didion, JP; Starmer et al.
Nature Communications null
Hiroko Inoue et al.
The Journal of biological chemistry, 277(44), 41674-41685 (2002-08-30)
The mammalian SWI/SNF-related complexes facilitate gene transcription by remodeling chromatin using the energy of ATP hydrolysis. The recruitment of these complexes to promoters remains poorly understood and may involve histone modifications or direct interactions with site-specific transcription factors or other
Essential role of ARID2 protein-containing SWI/SNF complex in tissue-specific gene expression.
Xu, F; Flowers, S; Moran, E
The Journal of Biological Chemistry null
Zuqin Nie et al.
Molecular and cellular biology, 23(8), 2942-2952 (2003-04-01)
The SWI/SNF family of chromatin-remodeling complexes has been discovered in many species and has been shown to regulate gene expression by assisting transcriptional machinery to gain access to their sites in chromatin. Several complexes of this family have been reported
Radhika Mathur et al.
Nature genetics, 49(2), 296-302 (2016-12-13)
Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are collectively mutated in ∼20% of all human cancers. Although ARID1A is the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis is unclear. Here we demonstrate that
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