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抗-BAF250a/ARID1a抗体，克隆PSG3

Name: 抗-BAF250a/ARID1a抗体，克隆PSG3
Brand: MM

clone PSG3, Upstate^®, from mouse

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

PSG3, monoclonal

Application:

IF, WB

Citations:

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

PSG3, monoclonal

species reactivity

human

manufacturer/tradename

Upstate^®

technique(s)

immunofluorescence: suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_006015.4, NM_139135.2

UniProt accession no.

O14497

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... ARID1A (8289)

General description

~270 kDa

Immunogen

GST融合蛋白，对应人BAF250a/ARID1a中部419个残基。

Application

抗BAF250a/ARID1A抗体，克隆PSG3是针对BAF250a/ARID1A的抗体，用于WB，ChIP，IC & IHC。

研究子类别
染色质生物学

转录因子

研究类别
表观遗传学&核功能

Biochem/physiol Actions

BAF250a/ARID1a

Physical form

100 μg蛋白A纯化的小鼠单克隆IgG，溶于100 μL 1X PBS（pH 7.0，0.1%叠氮化物）中。

形式：纯化

蛋白A纯化

Preparation Note

自运送之日起在-20°C下保存2年

Analysis Note

已通过免疫印迹进行常规评估。

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

存储类别

12 - Non Combustible Liquids

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Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.

Chandler, RL; Damrauer, JS; Raab, JR; Schisler, JC; Wilkerson, MD; Didion, JP; Starmer et al.

Nature Communications null

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice.

Radhika Mathur et al.

Nature genetics, 49(2), 296-302 (2016-12-13)

Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are collectively mutated in ∼20% of all human cancers. Although ARID1A is the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis is unclear. Here we demonstrate that

Nuclear factor 1 synergizes with progesterone receptor on the mouse mammary tumor virus promoter wrapped around a histone H3/H4 tetramer by facilitating access to the central hormone-responsive elements.

Guillermo Pablo Vicent et al.

The Journal of biological chemistry, 285(4), 2622-2631 (2009-11-27)

Steroid hormones induce transcription of their responsive genes by complex mechanisms including synergism between the hormone receptors and other transcription factors. On the mouse mammary tumor virus (MMTV) promoter progesterone induction is mediated by the reciprocal synergism between progesterone receptor

Xiaomei Wang et al.

The Biochemical journal, 383(Pt 2), 319-325 (2004-06-02)

p270 (ARID1A) is a member of the ARID family of DNA-binding proteins and a subunit of human SWI/SNF-related complexes, which use the energy generated by an integral ATPase subunit to remodel chromatin. ARID1B is an independent gene product with an

Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors.

Hiroko Inoue et al.

The Journal of biological chemistry, 277(44), 41674-41685 (2002-08-30)

The mammalian SWI/SNF-related complexes facilitate gene transcription by remodeling chromatin using the energy of ATP hydrolysis. The recruitment of these complexes to promoters remains poorly understood and may involve histone modifications or direct interactions with site-specific transcription factors or other

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