04-147
抗-ASC抗体，克隆2EI-7
clone 2EI-7, from mouse
别名:
Caspase recruitment domain-containing protein 5, PYD and CARD domain containing, PYD and CARD domain-containing protein, Target of methylation-induced silencing 1, apoptosis-associated speck-like protein containing a CARD, caspase recruitment domain prot
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2EI-7, monoclonal
Application:
flow cytometry
western blot
western blot
Species reactivity:
mouse
Citations:
38
Technique(s):
flow cytometry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-ASC抗体，克隆2EI-7, clone 2EI-7, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
2EI-7, monoclonal
species reactivity
mouse
species reactivity (predicted by homology)
human (based on 100% sequence homology)
technique(s)
flow cytometry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PYCARD(29108)
Analysis Note
对照
小鼠脾组织裂解液
小鼠脾组织裂解液
已通过蛋白质印迹在小鼠脾组织裂解液中进行了评估。
蛋白质印迹分析： 0.5 µg/mL的该抗体在小鼠脾组织裂解液中检测到ASC。
蛋白质印迹分析： 0.5 µg/mL的该抗体在小鼠脾组织裂解液中检测到ASC。
Application
使用该抗ASC抗体，克隆2EI-7检测ASC，已验证可用于WB、FC。
研究子类别
凋亡-附加
凋亡-附加
研究类别
炎症 & 免疫学
炎症 & 免疫学
Biochem/physiol Actions
该抗体可识别ASC。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
~22 kDa
凋亡受包含分子和蛋白酶的胱天蛋白酶家族的死亡结构域（DD）和/或胱天蛋白酶募集结构域（CARD）调节。含有细胞死亡调节剂的CARD包括RAIDD，RICK，Bcl10，Apaf-1，ARC，半胱天冬酶-2和半胱天冬酶-9。已经在人和小鼠中鉴定出一种新的含有CARD结构域的蛋白质，并将其命名为ASC和TMS1。ASC/TMS1的不规则表达通过激活半胱天冬酶-9诱导细胞凋亡，并抑制人乳腺癌细胞的存活。ASC/TMS1的过表达诱导DNA片段化。ASC/TMS1在多种人类和小鼠组织中表达。
Immunogen
全长重组人ASC。
表位：未知
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
形式：纯化
纯化的小鼠单克隆IgG1κ溶于含0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05％叠氮化钠的缓冲液中。
蛋白G纯化
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Sonal Khare et al.
Nature immunology, 15(4), 343-353 (2014-02-18)
The innate immune system responds to infection and tissue damage by activating cytosolic sensory complexes called 'inflammasomes'. Cytosolic DNA is sensed by AIM2-like receptors (ALRs) during bacterial and viral infections and in autoimmune diseases. Subsequently, recruitment of the inflammasome adaptor
Wei Zhu et al.
Neuroscience, 343, 77-84 (2016-12-08)
Lipopolysaccharide (LPS) might affect the central nervous system by causing neuroinflammation, which subsequently leads to brain damage and dysfunction. In this study, we evaluated the role of nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome activation in long-term behavioral alterations
Chromatin dynamics during DSB repair.
Martin Falk,Emilie Lukasova,Barbora Gabrielova,Vladan Ondrej,Stanislav Kozubek
Biochimica et Biophysica Acta null
Tiantian Tang et al.
Nature communications, 8(1), 202-202 (2017-08-06)
The NLRP3 inflammasome can sense different pathogens or danger signals, and has been reported to be involved in the development of many human diseases. Potassium efflux and mitochondrial damage are both reported to mediate NLRP3 inflammasome activation, but the underlying
Sung-Soo Jung et al.
American journal of physiology. Lung cellular and molecular physiology, 308(10), L1058-L1067 (2015-03-15)
Inflammasomes are cytosolic protein complexes that promote the cleavage of caspase-1, which leads to the maturation and secretion of proinflammatory cytokines, including interleukin-1β (IL-1β) and IL-18. Among the known inflammasomes, the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3)-dependent inflammasome is
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