04-1470
Anti-OX40L (CD252) Antibody, clone RM134L
clone RM134L, from rat
别名:
Tumor necrosis factor ligand superfamily member 4, OX40 ligand, OX40L, CD252
产品名称
Anti-OX40L (CD252) Antibody, clone RM134L, clone RM134L, from rat
isotype
IgG2bκ
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
RM134L, monoclonal
species reactivity
mouse
technique(s)
flow cytometry: suitable
immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Tnfsf4(22164)
Analysis Note
Control
Mouse OX40L/L5178Y cells
Mouse OX40L/L5178Y cells
Evaluated by Flow Cytometry in mouse OX40L/L5178Y cells.
Flow Cytometry Analysis: 10 µg of this antibody detected OX40L in mouse OX40L/L5178Y cells.
Flow Cytometry Analysis: 10 µg of this antibody detected OX40L in mouse OX40L/L5178Y cells.
Application
Anti-OX40L (CD252) Antibody, clone RM134L detects level of OX40L (CD252) & has been published & validated for use in Flow Cytometry & IHC.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse lung tissue. (Hoshino, A., et al. (2003). Eur. J. Immunol. 33:861–869.)
Biochem/physiol Actions
This antibody recognizes the extracellular domain of OX40L.
General description
22 kDa calculated
OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.
Immunogen
Mouse OX40L cDNA-transfected NRK cells
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Akihiko Hoshino et al.
European journal of immunology, 33(4), 861-869 (2003-04-03)
Bronchial asthma is characterized by massive infiltration of eosinophils and airway hyperreactivity (AHR), which are caused by overproduction of Th2 cytokines (IL-4, IL-5, and IL-13) by allergen-specific T cells. We recently demonstrated a critical contribution of OX40 ligand (OX40L) to
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