Anti-PD-1 Antibody, clone RMP1-14

32 kDa calculated

PD-1 (Programmed cell death protein 1, CD279) is a single-pass type 1 transmembrane protein that contains an Ig-like V-type domain on the extracellular region and a tyrosine-based motif on the intracellular region. PD-1 functions as an immunoreceptor that is activated by the PD-L1 ligand. PD-1 is expressed on the surface of activated T- and B-cells. It plays an inhibitory role on T-cell function, and may block T-cell—mediated events such as the proliferation of lymphocytes and the secretion of cytokines. PD-1 may therefore negatively regulate immune responses, and disruption of PD-1 function may affect tolerance.

Epitope: Extracellular Domain

Recombinant protein corresponding to mouse PD-1.

Detect PD-1 using this Anti-PD-1 Antibody, clone RMP1-14 validated for use in Flow Cytometry.

Research Category
Signaling

Research Sub Category
Apoptosis - Additional

Format: Purified

Protein G Purified

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
BHK cells

Evaluated by Flow Cytometry in BHK cells.

Flow Cytometry Analysis: 0.5 µg of this antibody detected PD-1 in BHK cells.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.