04-1550
抗-SC-35抗体，克隆1SC-4F11
ascites fluid, clone 1SC-4F11, from mouse
别名:
Protein PR264, Splicing component, 35 kDa, Splicing factor SC35, splicing factor, arginine/serine-rich 2
产品名称
抗-SC-35抗体，克隆1SC-4F11, ascites fluid, clone 1SC-4F11, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
1SC-4F11, monoclonal
species reactivity
human, mouse, rat
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SRSF2(6427)
Physical form
纯化的小鼠单克隆IgG1κ 无防腐剂腹水腹水。
未纯化
Analysis Note
对照
A431细胞裂解液
A431细胞裂解液
通过蛋白质印迹对A431细胞裂解液进行了评估。
蛋白质印迹分析：该抗体的1：1000的稀释液在10 µg A431细胞裂解液中检测到Sc35。
蛋白质印迹分析：该抗体的1：1000的稀释液在10 µg A431细胞裂解液中检测到Sc35。
Application
免疫细胞化学分析：代表性批次的1：500稀释液在NIH/3T3细胞中检测到SC35。
抗SC-35抗体，克隆1SC-4F11是小鼠单克隆抗体，用于检测SC-35（也称为蛋白PR264，剪接因子SC35），& 已在WB，ICC中得到验证。
研究子类别
RNA代谢&结合蛋白
RNA代谢&结合蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
该抗体可识别SC35。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
SC-35也称为剪接因子SC35和剪接因子，富含精氨酸/丝氨酸2。该蛋白由SFRS2基因编码，是剪接因子SR家族的成员。SC-35参与前mRNA剪接，并存在于高度富含poly(A)RNA的细胞核中。这些核体称为斑点，SC 35结构域或剪接因子区室（SFC）。这些机构的目的仍然存在广泛争议。斑点在很大程度上（如果不是完全的话）对应于称为染色质间颗粒簇（IGC）的超结构。SC3-35是前mRNA剪接事件所必需的，并且高度参与剪接体相互作用和组装。SC-35是组装ATP依赖性剪接复合物所必需的。前mRNA与U1和U2 snRNP之间的ATP依赖性通讯也是必要的。
~35 kDa
Immunogen
对应于人SC35的卵清蛋白偶联线性肽。
表位：未知
Preparation Note
自收到之日起在-20°C可稳定保存1年。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于 -20°C。避免反复冻融循环，以免损坏IgG和影响产品性能。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于 -20°C。避免反复冻融循环，以免损坏IgG和影响产品性能。
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Joseph Pangallo et al.
Blood, 135(13), 1032-1043 (2020-01-22)
Genes encoding the RNA splicing factors SF3B1, SRSF2, and U2AF1 are subject to frequent missense mutations in clonal hematopoiesis and diverse neoplastic diseases. Most "spliceosomal" mutations affect specific hotspot residues, resulting in splicing changes that promote disease pathophysiology. However, a
Hanna Kędzierska et al.
International journal of molecular sciences, 17(10) (2016-10-01)
Serine and arginine rich splicing factor 2(SRSF2) belongs to the serine/arginine (SR)-rich family of proteins that regulate alternative splicing. Previous studies suggested that SRSF2 can contribute to carcinogenic processes. Clear cell renal cell carcinoma (ccRCC) is the most common subtype
Yongchao Liu et al.
Cells, 9(4) (2020-04-16)
The ratio control of 4R-Tau/3R-Tau by alternative splicing of Tau exon 10 is important for maintaining brain functions. In this study, we show that hnRNP A1 knockdown induces inclusion of endogenous Tau exon 10, conversely, overexpression of hnRNP A1 promotes
Ainhoa Martínez-Pizarro et al.
PLoS genetics, 14(4), e1007360-e1007360 (2018-04-24)
Phenylketonuria (PKU), one of the most common inherited diseases of amino acid metabolism, is caused by mutations in the phenylalanine hydroxylase (PAH) gene. Recently, PAH exon 11 was identified as a vulnerable exon due to a weak 3' splice site
E Werwein et al.
Cell death & disease, 4, e511-e511 (2013-03-02)
B-Myb is a highly conserved member of the Myb transcription factor family that has essential roles in cell-cycle progression. Recent work has suggested that B-Myb is also involved in the cellular DNA-damage response. Here, we have investigated the fate of
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