05-1100-M
抗磺基酪氨酸抗体，克隆Sulfo-1C-A2
clone Sulfo-1C-A2, Upstate®, from mouse
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
Sulfo-1C-A2, monoclonal
Species reactivity:
human, mouse, bovine, porcine
Application:
ELISA, IP, WB
Citations:
4
biological source
mouse
antibody form
culture supernatant
antibody product type
primary antibodies
clone
Sulfo-1C-A2, monoclonal
species reactivity
human, mouse, bovine, porcine
species reactivity (predicted by homology)
all
manufacturer/tradename
Upstate®
technique(s)
ELISA: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG2aκ
Quality Level
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General description
磺基酪氨酸是分泌蛋白，质膜蛋白和溶酶体蛋白的常见翻译后修饰。硫酸化反应由反式高尔基体网络中的特定磺基转移酶催化。酪氨酸硫酸化发生在所有多细胞生物中，并且细胞总蛋白质含量中高达1%的酪氨酸可以被硫酸化。磺基酪氨酸介导许多受体-配体结合相互作用，包括P-选择蛋白糖蛋白配体-1与P-选择蛋白的相互作用，因子VIII与血管性血友病因子的结合以及凝血酶和水蛭素之间的相互作用。磺基酪氨酸还参与几种寄生虫和病毒的进入。例如，病毒进入宿主细胞需要HIV-1共受体CCR5的酪氨酸硫酸化，而Duffy抗原/趋化因子受体的酪氨酸硫酸化对于疟疾寄生虫间日疟原虫侵袭红细胞至关重要。
该克隆源自Kehoe et al.，2006中描述的抗体。
该克隆源自Kehoe et al.，2006中描述的抗体。
n/a
Application
用抗磺基酪氨酸抗体，克隆Sulfo-1C-A2（小鼠单克隆抗体）检测磺基酪氨酸，已在WB、IP、ELISA中起作用。
Biochem/physiol Actions
预测该抗体可识别任何磺基酪氨酸，而与周围的氨基酸序列无关。
Physical form
形式：纯化
Analysis Note
使用硫酸酯酶处理的牛纤维蛋白原与未处理的纤维蛋白原进行测定。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.
Pejchal, Robert, et al.
Proceedings of the National Academy of Sciences of the USA, 107, 11483-11488 (2010)
Yorihiro Nishimura et al.
PLoS pathogens, 6(11), e1001174-e1001174 (2010-11-17)
Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease, a common febrile disease in children; however, EV71 has been also associated with various neurological diseases including fatal cases in large EV71 outbreaks particularly
Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum.
Friedman, James, et al.
Testing, 7, e37648-e37648 (2012)
Juan Xu et al.
PloS one, 8(3), e56114-e56114 (2013-03-09)
The latent membrane protein 1 (LMP1), which is encoded by the Epstein-Barr virus (EBV), is an important oncogenic protein that is closely related to carcinogenesis and metastasis of nasopharyngeal carcinoma (NPC), a prevalent cancer in China. We previously reported that
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