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05-23-2101

Vasoactive Intestinal Peptide, Human, Porcine, and Rat

Name: Vasoactive Intestinal Peptide, Human, Porcine, and Rat
Brand: MM

Acts as a mitogenic factor for embryonic neurons in the sympathetic nervous system.

别名:

Vasoactive Intestinal Peptide, Human, Porcine, and Rat, VIP

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关于此项目

经验公式（希尔记法）:

C₁₄₇H₂₃₈N₄₄O₄₂S

化学文摘社编号:

40077-57-4

分子量:

3325.80

NACRES:

NA.77

UNSPSC Code:

12352202

MDL number:

MFCD00167535

Assay:

≥95% (HPLC)

Form:

lyophilized solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic)

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属性

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white to off-white

solubility

5% acetic acid: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C147H237N43O43S/c1-18-75(12)115(142(229)180-96(56-72(6)7)131(218)183-104(145(232)233)63-110(155)200)188-139(226)106(68-192)185-134(221)101(62-109(154)199)177-130(217)95(55-71(4)5)174-132(219)97(58-81-37-41-84(195)42-38-81)175-125(212)88(33-23-26-49-149)167-123(210)89(34-24-27-50-150)171-140(227)113(73(8)9)186-118(205)76(13)164-121(208)93(47-53-234-17)170-127(214)92(45-46-107(152)197)169-122(209)87(32-22-25-48-148)166-124(211)90(35-28-51-161-146(156)157)168-129(216)94(54-70(2)3)173-126(213)91(36-29-52-162-147(158)159)172-143(230)116(78(15)193)189-136(223)98(59-82-39-43-85(196)44-40-82)176-133(220)100(61-108(153)198)178-135(222)103(65-112(203)204)182-144(231)117(79(16)194)190-137(224)99(57-80-30-20-19-21-31-80)181-141(228)114(74(10)11)187-119(206)77(14)165-128(215)102(64-111(201)202)179-138(225)105(67-191)184-120(207)86(151)60-83-66-160-69-163-83/h19-21,30-31,37-44,66,69-79,86-106,113-117,191-196H,18,22-29,32-36,45-65,67-68,148-151H2,1-17H3,(H2,152,197)(H2,153,198)(H2,154,199)(H2,155,200)(H,160,163)(H,164,208)(H,165,215)(H,166,211)(H,167,210)(H,168,216)(H,169,209)(H,170,214)(H,171,227)(H,172,230)(H,173,213)(H,174,219)(H,175,212)(H,176,220)(H,177,217)(H,178,222)(H,179,225)(H,180,229)(H,181,228)(H,182,231)(H,183,218)(H,184,207)(H,185,221)(H,186,205)(H,187,206)(H,188,226)(H,189,223)(H,190,224)(H,201,202)(H,203,204)(H,232,233)(H4,156,157,161)(H4,158,159,162)/t75-,76-,77-,78+,79+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-,117-/m0/s1

InChI key

VBUWHHLIZKOSMS-RIWXPGAOSA-N

说明

General description

Acts as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Inhibits the growth of human small-cell lung carcinoma (SCLC) both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC. Nitric oxide stimulates the release of this peptide.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Mitogenic factor for embryonic neurons

Product does not compete with ATP.

Reversible: no

Packaging

Yes

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂

Maruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
Bakker, R., et al. 1993. Am. J. Physiol.264, R362.
Grider, J.R. 1993. Am. J. Physiol.264, G334.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Vasoactive intestinal peptide inhibits human small-cell lung cancer proliferation in vitro and in vivo.

K Maruno et al.

Proceedings of the National Academy of Sciences of the United States of America, 95(24), 14373-14378 (1998-11-25)

Small-cell lung carcinoma (SCLC) is an aggressive, rapidly growing and metastasizing, and highly fatal neoplasm. We report that vasoactive intestinal peptide inhibits the proliferation of SCLC cells in culture and dramatically suppresses the growth of SCLC tumor-cell implants in athymic

VIP, serotonin, and epinephrine modulate the ion selectivity of tight junctions of goldfish intestine.

R Bakker et al.

The American journal of physiology, 264(2 Pt 2), R362-R368 (1993-02-01)

Bidirectional fluxes of Cl- across isolated and stripped goldfish intestinal epithelium mounted in Ussing-type chambers increased after addition of 8-bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP), suggesting an increase of the paracellular permeability for Cl-. Confirming this, the addition of 8-Br-cAMP to the

Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis.

J R Grider

The American journal of physiology, 264(2 Pt 1), G334-G340 (1993-02-01)

Involvement of vasoactive intestinal peptide (VIP) and nitric oxide (NO) in neurally induced relaxation was examined in smooth muscle from rat colon. Relaxation induced by field stimulation or radial stretch (i.e., descending relaxation phase of the peristaltic reflex) was accompanied

全球贸易项目编号

货号	GTIN
05-23-2101-1MG	04055977226645
05-23-2101-0.5MG	04055977226638