05-584
抗-Tie2/TEK抗体，克隆Ab33
clone Ab33, Upstate®, from mouse
别名:
CD202b antigen, TEK tyrosine kinase, endothelial, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK, soluble TIE2 variant 1, soluble TIE2 variant 2, venous malformations, multip
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
Ab33, monoclonal
Application:
IHC, IP, WB
Citations:
36
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
Ab33, monoclonal
species reactivity
human, rat, pig, mouse
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TEK(7010)
General description
TIE2（具有Ig和EGF同源结构域2的酪氨酸激酶）几乎仅在小鼠，大鼠和人的内皮细胞中表达。该受体具有独特的细胞外结构域，该结构域包含两个免疫球蛋白样环，这些环被三个表皮生长因子样重复序列隔开，这些重复序列与三个纤连蛋白III型重复序列相连。受体的配体是血管生成素1。TIE2的缺陷与遗传性静脉畸形有关。TIE2信号通路似乎对于静脉形态发生中的内皮细胞-平滑肌细胞通讯至关重要。
145 kDa
Immunogen
对应于人Tie2/TEK残基1-745的融合蛋白，具有从感染的SF-9细胞纯化的C端His6-标签。克隆Ab33
Application
免疫沉淀：根据独立实验室的报道，该抗体可免疫沉淀Tie2/Tek。
免疫组化：报告在经Triton处理的冷冻切片中检测到Tie2/Tek。
此抗体不适用于石蜡包埋切片。
免疫组化：报告在经Triton处理的冷冻切片中检测到Tie2/Tek。
此抗体不适用于石蜡包埋切片。
该抗Tie2/TEK抗体，克隆Ab33已验证可用于 WB、IP、IH中的Tie2/TEK检测。
Biochem/physiol Actions
识别Tie2/TEK，Mr 145kDa
Physical form
形式：纯化
纯化的小鼠单克隆IgG1κ，添加甘油至30％之前，溶于含有0.1M Tris-甘氨酸、0.15M NaCl、0.05％叠氮化钠的缓冲液（pH 7.4）中。在-20°C为液体形式。
Analysis Note
已通过蛋白质印迹对HUVEC细胞的RIPA裂解液进行了评估。
蛋白质印迹分析：0.2-1 μg/mL该抗体在来自HUVEC细胞的RIPA裂解液中检测到Tie2/TEK。
蛋白质印迹分析：0.2-1 μg/mL该抗体在来自HUVEC细胞的RIPA裂解液中检测到Tie2/TEK。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Krystyna Teichert-Kuliszewska et al.
Circulation research, 98(2), 209-217 (2005-12-17)
Mutations in the bone morphogenetic protein (BMP) receptor-2 (BMPR2) have been found in patients with idiopathic pulmonary arterial hypertension (IPAH); however, the mechanistic link between loss of BMPR2 signaling and the development of pulmonary arterial hypertension is unclear. We hypothesized
Howard Leong-Poi et al.
Circulation research, 101(3), 295-303 (2007-06-23)
Current methods of gene delivery for therapeutic angiogenesis are invasive, requiring either intraarterial or intramuscular administration. A noninvasive method of gene delivery has been developed using ultrasound-mediated destruction of intravenously administered DNA-bearing carrier microbubbles during their microcirculatory transit. Here we
Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.
Wong, A L, et al.
Circulation Research, 81, 567-574 (1997)
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
Lin, P, et al.
Proceedings of the National Academy of Sciences of the USA, 95, 8829-8834 (1998)
Increased Expression of Angiopoietins and Tie2 in the Lungs of Chronic Asthmatic Mice.
Makinde TO, Agrawal DK
American Journal of Respiratory Cell and Molecular Biology null
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