05-672
抗二甲基组蛋白H4（Lys207）抗体（克隆6G7/H4）
clone 6G7/H4, Upstate®, from mouse
别名:
H4K20me2, Histone H4 (di methyl K20)
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
6G7/H4, monoclonal
Species reactivity:
human, bovine, mouse, rat
Application:
IHC, IP, WB
Citations:
4
biological source
mouse
antibody product type
primary antibodies
clone
6G7/H4, monoclonal
species reactivity
human, bovine, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
dimethylation (Lys20)
Quality Level
Gene Information
bovine ... H4C1(617905)
human ... H4C1(8359)
mouse ... H4C1(326619)
General description
10kDa
Immunogen
对应于人组蛋白H43的17-28位氨基酸的肽（RHRdimKVLRDNIQGC），赖氨酸20处二甲基化。
Application
使用在IP、WB、 IHC中验证过的抗二甲基组蛋白H4（Lys20）抗体（克隆6G7/H4，小鼠单克隆）检测二甲基组蛋白H4（Lys20），也称为H4K20me2、组蛋白H4（二甲基K20）。
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
甲基组蛋白H4
Physical form
PBS
形式：纯化
蛋白G层析
Preparation Note
在-20°C下可保存2年
Analysis Note
已通过免疫印迹法对HeLa核提取物进行常规评估
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Kenichi Nishioka et al.
Molecular cell, 9(6), 1201-1213 (2002-06-28)
We have purified a human histone H4 lysine 20 methyltransferase and cloned the encoding gene, PR/SET07. A mutation in Drosophila pr-set7 is lethal: second instar larval death coincides with the loss of H4 lysine 20 methylation, indicating a fundamental role
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.
Frederick A Mallette,Francesca Mattiroli,Gaofeng Cui,Leah C Young,Michael J Hendzel et al.
The Embo Journal null
Ai-Shun Guo et al.
Molecular medicine reports, 14(5), 4613-4621 (2016-10-26)
The present study aimed to investigate the differential expression and clinical significance of histone methyltransferase G9a, histone H3K9me2 and histone H3K9me1 in human brain glioma and adjacent tissue samples. It also aimed to observe the effect and mechanism of BIX‑01294, as
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