06-1049
Anti-Axin-1 Antibody
from rabbit, purified by affinity chromatography
别名:
Axin-1, Axis inhibition protein 1, hAxin
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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IHC, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Axin1(12005)
General description
Axin-1 is a beta-catenin destruction complex scaffold protein and a transcription factor of the Wnt signaling pathway. Variation in the Wnt signaling pathway has been associated with the formation of some primary human cancers. Axin-1 mutation has been linked to oral squamous cell carcinoma. Axin-1 binds to GSK3alpha and activates the Wnt signaling pathway which is shown to be associated with growth and development of cells. Axin-1 has also been implicated in Alzheimer′s disease.
~110 kDa observed. An uncharacterized band appears at ~40 and 45 kDa in some lysates.
Immunogen
KLH-conjugated linear peptide corresponding to human Axin-1.
Application
Anti-Axin-1 Antibody is an antibody against Axin-1 for use in WB, IC, IH.
Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Axin-1 in A431 and HeLa cells.
Immunohistochemistry Analysis: 1:1,000 dilution from a representative lot detected Axin-1 in human kidney and human skin tissues.
Immunohistochemistry Analysis: 1:1,000 dilution from a representative lot detected Axin-1 in human kidney and human skin tissues.
Analysis Note
Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Axin-1 on 10 µg of HEK293 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Axin-1 on 10 µg of HEK293 cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Shiwei Zhou et al.
Pharmaceutics, 13(3) (2021-04-04)
Genetic evidence has indicated that β-catenin plays a vital role in glucose and lipid metabolism. Here, we investigated whether pyrvinium, an anthelmintic agent previously reported as a down-regulator of cellular β-catenin levels, conferred any metabolic advantages in treatment of metabolic
Anuradha Kumari et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(4), e21539-e21539 (2021-03-21)
An aberrant accumulation of nuclear β-catenin is closely associated with the augmentation of cancer malignancy. In this work, we report that several microtubule-targeting agents (MTAs) such as vinblastine, taxol, and C12 (combretastatin-2-aminoimidazole analog) inhibit Wnt/β-catenin signaling in oral squamous cell
Yiwei Li et al.
Cell stem cell, 28(1), 63-78 (2020-10-15)
Enormous amounts of essential intracellular events are crowdedly packed inside picoliter-sized cellular space. However, the significance of the physical properties of cells remains underappreciated because of a lack of evidence of how they affect cellular functionalities. Here, we show that
Ludovic Zimmerlin et al.
Development (Cambridge, England), 143(23), 4368-4380 (2016-11-02)
The derivation and maintenance of human pluripotent stem cells (hPSCs) in stable naïve pluripotent states has a wide impact in human developmental biology. However, hPSCs are unstable in classical naïve mouse embryonic stem cell (ESC) WNT and MEK/ERK signal inhibition
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