biological source
rabbit
antibody product type
primary antibodies
clone
polyclonal
species reactivity
pig, rat, human, mouse
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Quality Level
Gene Information
human ... SHC1(6464)
General description
46, 52, 66 kDa
Immunogen
Recombinant GST fusion protein corresponding to amino acids 366-473 of human SHC-SH2
Application
Anti-SHC Antibody is an antibody against SHC for use in IH, IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
Biochem/physiol Actions
Recognizes SHC proteins.
Physical form
Format: Purified
Immunoaffinity Purified immunoglobulin in 0.2 Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Protein A purified
Preparation Note
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Analysis Note
Control
Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
routinely evaluated by immunoblot on RIPA lysates from human A431 carcinoma cells or mouse 3T3 RIPA cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10-13 - German Storage Class 10 to 13
法规信息
新产品
此项目有
Kevin D Wright et al.
Breast cancer research : BCR, 21(1), 74-74 (2019-06-17)
SHC1 proteins (also called SHCA) exist in three functionally distinct isoforms (p46SHC, p52SHC, and p66SHC) that serve as intracellular adaptors for several key signaling pathways in breast cancer. Despite the broad evidence implicating SHC1 gene products as a central mediator
Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2.
V M Gelfanov, G S Burgess, S Litz-Jackson, A J King, M S Marshall, H Nakshatri, H S Boswell
Blood null
Fibroblast growth factor receptor (FGFR) and candidate signaling molecule distribution within rat and human retina.
Norbert Kinkl, Gregory S Hageman, Jose A Sahel, David Hicks
Molecular Vision null
Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells.
G Venkatakrishnan, R Salgia, J E Groopman
The Journal of Biological Chemistry null
Z Tu et al.
Blood, 98(7), 2028-2038 (2001-09-25)
SH2-containing inositol 5'-phosphatase (SHIP) modulates the activation of immune cells after recruitment to the membrane by Shc and the cytoplasmic tails of receptors. A novel SHIP isoform of approximately 104 kd expressed in primitive stem cell populations (s-SHIP) is described.
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