生物来源
rabbit
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
mouse, human, rat
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... HDAC5(10014)
一般描述
160 kDa
免疫原
KLH-conjugated synthetic peptides corresponding to amino acids 536-545 and 194-206 (C-TKTGELPRQP and C-KSKEPTPGGLNHS) of human HDAC5
应用
Detect HDAC5 also known as histone deacetylase 5 with Anti-HDAC5 Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
Weaker staining noticed in mouse and rat versus human.
生化/生理作用
HDAC5
外形
Protein A chromatography
0.1M Tris-glycine, pH 7.4, 0.15M NaCl and 0.05% sodium azide.
Format: Purified
制备说明
Stable for 1 year at 2-8°C from date of receipt.
分析说明
routinely evaluated by immunoblot on HeLa nuclear extract or HeLa whole cell lysate
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated--implications for colorectal epithelial homeostasis.
Sian H Leech,Caroline A Evans,Leila Shaw,Chi H Wong,Joanne Connolly,John R Griffiths et al.
Proteomics null
Dhiraj G Kabra et al.
Nature communications, 7, 10782-10782 (2016-03-01)
Hypothalamic leptin signalling has a key role in food intake and energy-balance control and is often impaired in obese individuals. Here we identify histone deacetylase 5 (HDAC5) as a regulator of leptin signalling and organismal energy balance. Global HDAC5 KO
Hongbo Ling et al.
Cell cycle (Georgetown, Tex.), 11(20), 3779-3791 (2012-10-02)
Centrosome duplication is controlled both negatively and positively by a number of proteins. The activities and stabilities of those regulatory proteins are in many cases controlled by posttranslational modifications. Although acetylation and deacetylation are highly common posttranslational modifications, their roles
Lauren E Kernochan et al.
Human molecular genetics, 14(9), 1171-1182 (2005-03-18)
Increasing survival motor neuron 2 (SMN2) gene expression may be an effective strategy for the treatment of spinal muscular atrophy (SMA). Histone deacetylase (HDAC) inhibitors have been shown to increase SMN transcript and protein levels, but the specific role of
Gaurav Patki et al.
Physiology & behavior, 130, 135-144 (2014-04-16)
Social defeat (SD) induced stress causes physiological and behavioral deficits in rodents, including depression and anxiety-like behaviors, as well as memory impairment. Anxiolytic and mood elevating effects of physical exercise are also known. However, rescue effect of physical exercise in
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