biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
species reactivity (predicted by homology)
all
technique(s)
immunohistochemistry: suitable (paraffin)
shipped in
wet ice
target post-translational modification
unmodified
General description
当G蛋白偶联受体(GPCR)结合细胞表面上的各种配体时,环磷酸腺苷或cAMP是腺苷环化酶ATP的细胞内副产物。环AMP充当跨细胞膜的信号转导的第二信使,并且是激酶激活的一部分。它调节胰高血糖素和肾上腺素的作用以及钙离子通过离子通道的运动。由于它直接受GPCR激活的影响,因此在发现治疗药物时将cAMP作为监测GPCR的一种手段进行研究。
Immunogen
结合BSA的2′O-琥珀酰环AMP
Application
抗cAMP抗体可检测cAMP水平 & 已出版&并经过验证可用于IH(P)。
研究子类别
GPCR, cAMP/cGMP & 钙信号传导
GPCR, cAMP/cGMP & 钙信号传导
研究类别
信号传导
信号传导
Biochem/physiol Actions
对cAMP具有特异性,在浓度至1 mM时与其他核苷酸无交叉反应。与固定在组织中的cAMP或乙酰化的cAMP反应。在RIA或EIA分析中,与游离的非乙酰化cAMP不反应。
Physical form
未纯化的兔血清
稀释的血清在不含防腐剂的PBS中以液体形式呈现。
Preparation Note
自收到之日起,未稀释的等分试样在-20°C下保存。应避免反复冻/融循环。
Analysis Note
对照
大鼠海马和小脑组织
大鼠海马和小脑组织
已通过免疫组织化学在大鼠海马和小脑组织中进行评估。
免疫组织化学分析:该批次1:100稀释液在大鼠海马和小脑组织中检测到cAMP。
免疫组织化学分析:该批次1:100稀释液在大鼠海马和小脑组织中检测到cAMP。
Other Notes
替代:MABN1026
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 07-1497 | 04053252322914 |