生物来源
rabbit
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human, mouse
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
phosphorylation (pTyr191)
基因信息
human ... LAT(27040)
mouse ... Lat(16797)
一般描述
36kDa
免疫原
peptide (SREpYVNVSPEQQ-C) corresponding to amino acids 188-195 of human LAT and amino acids 192-203 of mouse LAT
应用
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
Immunoglobulins & Immunology
This Anti-phospho-LAT (Tyr191) Antibody is validated for use in WB for the detection of phospho-LAT (Tyr191).
生化/生理作用
LAT phosphorylated on tyrosine 191
外形
Protein A chromatography
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
制备说明
2 years at -20°C
分析说明
routinely evaluated by immunoblot on RIPA lysates from Jurkat cells stimulated with anti-T-cell receptor monoclonal antibody, clone C305
其他说明
Replaces: 04-467
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
Kwok Ho Yip et al.
Nature communications, 7, 13198-13198 (2016-10-28)
Cross-linkage of the high-affinity immunoglobulin E (IgE) receptor (FcɛRI) on mast cells by antigen ligation has a critical role in the pathology of IgE-dependent allergic disorders, such as anaphylaxis and asthma. Restraint of intracellular signal transduction pathways that promote release
Viktor Bugajev et al.
Cells, 12(16) (2023-08-26)
Signal transduction by the high-affinity IgE receptor (FcεRI) depends on membrane lipid and protein compartmentalization. Recently published data show that cells treated with 1-heptanol, a cell membrane fluidizer, exhibit changes in membrane properties. However, the functional consequences of 1-heptanol-induced changes
Claire Hivroz et al.
Methods in molecular biology (Clifton, N.J.), 1584, 355-368 (2017-03-04)
In T lymphocytes, the immune synapse is an active zone of vesicular traffic. Directional transport of vesicular receptors and signaling molecules from or to the immune synapse has been shown to play an important role in T-cell receptor (TCR) signal
Lucie Potuckova et al.
Frontiers in immunology, 9, 1771-1771 (2018-08-18)
C-terminal Src kinase (CSK) is a major negative regulator of Src family tyrosine kinases (SFKs) that play critical roles in immunoreceptor signaling. CSK is brought in contiguity to the plasma membrane-bound SFKs via binding to transmembrane adaptor PAG, also known
Delia I Fernández et al.
Thrombosis research, 228, 105-116 (2023-06-12)
The protein tyrosine phosphatase SHP2 (PTPN11) is a negative regulator of glycoprotein VI (GPVI)-induced platelet signal under certain conditions. Clinical trials with derivatives of the allosteric drug SHP099, inhibiting SHP2, are ongoing as potential therapy for solid cancers. Gain-of-function mutations
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