生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human, vertebrates, mouse
制造商/商品名称
Upstate®
技术
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG
运输
wet ice
靶向翻译后修饰
unmodified
一般描述
43-65 kDa
氨基酸瓜氨酸是肝脏从氨中解毒所必需的，氨是人体氧化的废物。瓜氨酸促进能量和帮助免疫系统。这种不寻常的氨基酸是在尿素循环中通过向鸟氨酸中加入二氧化碳和氨而形成的。接着与天冬氨酸结合形成精氨酸琥珀酸，然后被代谢成氨基酸精氨酸。
免疫原
线状肽，含瓜氨酸。
应用
用抗瓜氨酸抗体（兔多克隆抗体）检测瓜氨酸，已证明可用于WB & IHC。
研究子类别
常规翻译后修改
常规翻译后修改
研究类别
炎症 & 免疫学
炎症 & 免疫学
生化/生理作用
人角质化皮肤中的多重脱位角蛋白。 在富含甘氨酸的环境中优先与瓜氨酸残基反应。
外形
25mM Tris/Tris-HCl，pH 7.4，137mM NaCl、2.7mM KCl、0.02%叠氮化钠，然后添加甘油至30％
免疫亲和纯化
制备说明
自收到之日起，在2-8°C条件下可稳定保存1年。
分析说明
对准
人外角化层全细胞裂解液
人外角化层全细胞裂解液
通过免疫印迹对带剥人角膜外层全细胞裂解液进行常规评估
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
A Ishida-Yamamoto et al.
The Journal of investigative dermatology, 114(4), 701-705 (2000-03-25)
Citrulline-containing proteins, mainly originating from keratin K1 and formed by enzymatic deimination of arginine residues, have been identified in the cornified layers of human epidermis. We analyzed the localization and nature of the deiminated proteins in psoriatic epidermis. Immunostaining based
T Senshu et al.
Biochemical and biophysical research communications, 225(3), 712-719 (1996-08-23)
The upper layers of mammalian epidermis contain citrulline-containing proteins formed by enzymatic deimination of arginine residues. To study the role of protein deimination in epidermal differentiation, we identified deiminated proteins extracted from human epidermis. Major deiminated proteins were identified as
T Senshu et al.
Journal of dermatological science, 21(2), 113-126 (1999-10-08)
Citrulline residues are detected in keratins and filaggrin in the cornified layers of mammalian epidermis. Such citrulline residues are formed by the enzymatic deimination of arginine residues by peptidylarginine deiminases (EC 3.5.3.15). Major deiminated keratins are derived from keratin K1.
Akemi Ishida-Yamamoto et al.
The Journal of investigative dermatology, 118(2), 282-287 (2002-02-14)
The final step of keratinocyte differentiation, transition from the granular cells to the cornified cells, involves various post-translational modifications that include deimination of arginine residues. Major deiminated epidermal proteins are derived from K1. Two preferred deimination sites were identified in
R Yu et al.
Scandinavian journal of immunology, 87(4), e12654-e12654 (2018-02-28)
Hypoxia is a prominent microenvironment feature in a range of disorders including cancer, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel disease (IBD), infection and obesity. Hypoxia promotes biological functions of fibroblast-like synoviocytes via regulating hypoxia-inducible factor 1α (HIF1α). Dysregulated protein citrullination
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