生物来源
rabbit
抗体形式
serum
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
mouse, human
制造商/商品名称
Upstate®
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... H2BC1(255626)
mouse ... H2Bc1(319177)
一般描述
Mr 15kDa
免疫原
KLH-conjugated, synthetic peptide spanning amino acids 7-17 (...GATISKKGFKK...) of human testis/sperm specific histone H2B
应用
Anti-Histone H2B Antibody, testis variant is a Rabbit Polyclonal Antibody for detection of Histone H2B also known as Histone H2B & has been tested in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
生化/生理作用
Predicted to cross-react with rat based on sequence homology
histone H2B, testis variant
外形
Antiserum
制备说明
stable 2 years at -20°C from date of shipment
分析说明
routinely evaluated by immunoblot in whole cell extracts from mouse testis cells.
其他说明
Replaces: MABE15
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Distinctive chromatin in human sperm packages genes for embryo development.
Hammoud, SS; Nix, DA; Zhang, H; Purwar, J; Carrell, DT; Cairns, BR
Nature null
Aniket Patankar et al.
Clinical epigenetics, 13(1), 101-101 (2021-05-03)
Biological relevance of the major testis specific histone H2B variant (TH2B) in sperm is not fully understood. Studies in TH2A/TH2B double knockout male mice indicate its role in chromatin compaction and male fertility. Additionally, the presence of TH2B and TH2A
Isha Singh et al.
Frontiers in cell and developmental biology, 9, 755751-755751 (2021-12-24)
Testis-specific histone variants are crucial to promote open chromatin structure to enable nucleosome disassembly in the final stages of spermiogenesis. However, even after histone replacement, mature sperm retain a proportion of these variants, the function of which is unknown. The
Manjeet Kaur Gill-Sharma et al.
Clinical epigenetics, 4(1), 23-23 (2012-12-18)
The putative regulatory role of the male reproductive hormones in the molecular mechanism underlying chromatin condensation remains poorly understood. In the past decade, we developed two adult male rat models wherein functional deficits of testosterone or FSH, produced after treatments
Emilie Montellier et al.
Genes & development, 27(15), 1680-1692 (2013-07-26)
The conversion of male germ cell chromatin to a nucleoprotamine structure is fundamental to the life cycle, yet the underlying molecular details remain obscure. Here we show that an essential step is the genome-wide incorporation of TH2B, a histone H2B
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