biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... H2BC1(255626)
mouse ... H2Bc1(319177)
General description
Mr 15kDa
Immunogen
KLH-conjugated, synthetic peptide spanning amino acids 7-17 (...GATISKKGFKK...) of human testis/sperm specific histone H2B
Application
Anti-Histone H2B Antibody, testis variant is a Rabbit Polyclonal Antibody for detection of Histone H2B also known as Histone H2B & has been tested in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
Biochem/physiol Actions
Predicted to cross-react with rat based on sequence homology
histone H2B, testis variant
Physical form
Antiserum
Preparation Note
stable 2 years at -20°C from date of shipment
Analysis Note
routinely evaluated by immunoblot in whole cell extracts from mouse testis cells.
Other Notes
Replaces: MABE15
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Isha Singh et al.
Frontiers in cell and developmental biology, 9, 755751-755751 (2021-12-24)
Testis-specific histone variants are crucial to promote open chromatin structure to enable nucleosome disassembly in the final stages of spermiogenesis. However, even after histone replacement, mature sperm retain a proportion of these variants, the function of which is unknown. The
Distinctive chromatin in human sperm packages genes for embryo development.
Hammoud, SS; Nix, DA; Zhang, H; Purwar, J; Carrell, DT; Cairns, BR
Nature null
Aniket Patankar et al.
Clinical epigenetics, 13(1), 101-101 (2021-05-03)
Biological relevance of the major testis specific histone H2B variant (TH2B) in sperm is not fully understood. Studies in TH2A/TH2B double knockout male mice indicate its role in chromatin compaction and male fertility. Additionally, the presence of TH2B and TH2A
Negar Bagheri-Sereshki et al.
Biology of reproduction, 94(4), 81-81 (2016-02-26)
The coadministration of bleomycin, etoposide, and cisplatin (BEP) has increased the survival rate of testicular cancer patients to over 90%. Previous studies have demonstrated that BEP induces germ cell damage during the final stages of spermatogenesis, when major chromatin remodeling
Manjeet Kaur Gill-Sharma et al.
Clinical epigenetics, 4(1), 23-23 (2012-12-18)
The putative regulatory role of the male reproductive hormones in the molecular mechanism underlying chromatin condensation remains poorly understood. In the past decade, we developed two adult male rat models wherein functional deficits of testosterone or FSH, produced after treatments
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