biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... SFRP4(6424)
General description
55 kDa
Immunogen
Recombinant full length human GST-tagged SFRP4 protein.
Application
Anti-SFRP4 Antibody detects level of SFRP4 & has been published & validated for use in WB.
Immunoblot: 1:500-1:5000 dilution is recommended depending on cell type and method of stimulation.
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Research Category
Signaling
Signaling
Research Sub Category
Developmental Signaling
Developmental Signaling
Biochem/physiol Actions
Recognizes SFRP4
Physical form
Serum
Analysis Note
Routinely evaluated by immunoblot.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
Biao He et al.
Cancer research, 65(3), 743-748 (2005-02-12)
The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in tumorigenesis. Frequent promoter hypermethylation of SFRPs has been identified in human cancer. Restoration of SFRP function attenuates Wnt signaling and induces apoptosis in
Secreted frizzled-related protein 4 expression is positively associated with responsiveness to cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers.
Saran, U; Arfuso, F; Zeps, N; Dharmarajan, A
BMC Cell Biology null
Lisa G Horvath et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(2), 615-625 (2004-02-05)
Activation of the Wnt-signaling pathway is implicated in aberrant cellular proliferation in a variety of cancers. Secreted frizzled-related protein 4 (sFRP4) is a secreted protein with putative inhibitory activity of the Wnt-signaling cascade through binding and sequestering Wnt ligands. Because
Taranjit S Gujral et al.
PloS one, 5(4), e10024-e10024 (2010-04-13)
Aberrant Wnt signaling has been implicated in a wide variety of cancers and many components of the Wnt signaling network have now been identified. Much less is known, however, about how these proteins are coordinately regulated. Here, a broad, quantitative
W Roth et al.
Oncogene, 19(37), 4210-4220 (2000-09-12)
Cellular resistance to multiple proapoptotic stimuli and invasion of surrounding brain tissue by migrating tumor cells are main obstacles to an effective therapy for human malignant glioma. Here, we report that the Wnt family of embryonic differentiation genes modulate growth
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