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Merck
CN

09-724

Sigma-Aldrich

Anti-RNF110/PCGF2 Antibody

from rabbit, purified by affinity chromatography

别名:

DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, polycomb group ring finger 2

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关于此项目

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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生物来源

rabbit

质量水平

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

mouse, human, rat

种属反应性(根据同源性预测)

chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), horse (based on 100% sequence homology), macaque (based on 100% sequence homology)

技术

western blot: suitable

NCBI登记号

UniProt登记号

运输

wet ice

基因信息

human ... PCGF2(7703)

一般描述

Polycomb group ring finger 2, also known as PCGF2, is a transcriptional repressor. Polycomb group (PcG) of genes were first identified in Drosophila whereby these genes were required to sustain the stable repression of Hox cluster genes during development. Studies have shown that PCGF2 forms multimeric protein complexes associated with chromatin. In addition, PCGF2 may play a role in cell proliferation and/or neural cell development. PCGF2 is widely expressed in placenta, lung, and kidneys but expressed very little in skeletal muscle, liver, and pancreas.
~40 kDa

免疫原

KLH conjugated linear peptide corresponding to human RNF110/PCGF2.

应用

Anti-RNF110/PCGF2 Antibody is a Rabbit Polyclonal Antibody for detection of RNF110/PCGF2 also known as DNA-binding protein Mel-18, RING finger protein 110 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair
Western Blot (SNAP ID) Analysis: 2 µg/mL from a previous lot detected RNF110/PCGF2 in Western Blot (SNAP ID) Analysis.

生化/生理作用

This antibody recognizes RNF110/PCGF2.

外形

Affinity purified
Purifeid rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl with 0.05% sodium azide.

制备说明

Stable at 2-8°C for 1 year from date of receipt.

分析说明

Control
Human lung tissue lysate
Routinely evaluated by Western Blot in human lung tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected RNF110/PCGF2 in 10 µg of human lung tissue lysate.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10-13 - German Storage Class 10 to 13


分析证书(COA)

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Gergely Rona et al.
eLife, 7 (2018-07-10)
The mammalian FBXL10-RNF68-RNF2 ubiquitin ligase complex (FRRUC) mono-ubiquitylates H2A at Lys119 to repress transcription in unstressed cells. We found that the FRRUC is rapidly and transiently recruited to sites of DNA damage in a PARP1- and TIMELESS-dependent manner to promote
Hsan-au Wu et al.
The Journal of biological chemistry, 288(51), 36398-36408 (2013-11-07)
Cbx7 is one of five mammalian orthologs of the Drosophila Polycomb. Cbx7 recognizes methylated lysine residues on the histone H3 tail and contributes to gene silencing in the context of the Polycomb repressive complex 1 (PRC1). However, our knowledge of

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