09-724
Anti-RNF110/PCGF2 Antibody
from rabbit, purified by affinity chromatography
别名:
DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, polycomb group ring finger 2
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, rat
species reactivity (predicted by homology)
chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), horse (based on 100% sequence homology), macaque (based on 100% sequence homology)
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Quality Level
Gene Information
human ... PCGF2(7703)
General description
Polycomb group ring finger 2, also known as PCGF2, is a transcriptional repressor. Polycomb group (PcG) of genes were first identified in Drosophila whereby these genes were required to sustain the stable repression of Hox cluster genes during development. Studies have shown that PCGF2 forms multimeric protein complexes associated with chromatin. In addition, PCGF2 may play a role in cell proliferation and/or neural cell development. PCGF2 is widely expressed in placenta, lung, and kidneys but expressed very little in skeletal muscle, liver, and pancreas.
~40 kDa
Immunogen
KLH conjugated linear peptide corresponding to human RNF110/PCGF2.
Application
Anti-RNF110/PCGF2 Antibody is a Rabbit Polyclonal Antibody for detection of RNF110/PCGF2 also known as DNA-binding protein Mel-18, RING finger protein 110 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair
Cell Cycle, DNA Replication & Repair
Western Blot (SNAP ID) Analysis: 2 µg/mL from a previous lot detected RNF110/PCGF2 in Western Blot (SNAP ID) Analysis.
Biochem/physiol Actions
This antibody recognizes RNF110/PCGF2.
Physical form
Affinity purified
Purifeid rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable at 2-8°C for 1 year from date of receipt.
Analysis Note
Control
Human lung tissue lysate
Human lung tissue lysate
Routinely evaluated by Western Blot in human lung tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected RNF110/PCGF2 in 10 µg of human lung tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected RNF110/PCGF2 in 10 µg of human lung tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10-13 - German Storage Class 10 to 13
Gergely Rona et al.
eLife, 7 (2018-07-10)
The mammalian FBXL10-RNF68-RNF2 ubiquitin ligase complex (FRRUC) mono-ubiquitylates H2A at Lys119 to repress transcription in unstressed cells. We found that the FRRUC is rapidly and transiently recruited to sites of DNA damage in a PARP1- and TIMELESS-dependent manner to promote
Hsan-au Wu et al.
The Journal of biological chemistry, 288(51), 36398-36408 (2013-11-07)
Cbx7 is one of five mammalian orthologs of the Drosophila Polycomb. Cbx7 recognizes methylated lysine residues on the histone H3 tail and contributes to gene silencing in the context of the Polycomb repressive complex 1 (PRC1). However, our knowledge of
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