116765
Adenosine A 2A/A1 Receptor Antagonist
The Adenosine A2A/A1 Receptor Antagonist controls the biological activity of Adenosine A2A/A1 Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications.
别名:
Adenosine A 2A/A1 Receptor Antagonist
SMILES string
NC(N=C1C2=CC=CC=C2)=NC(C3=C4C=CC(OCCN5CCOCC5)=C3)=C1C4=O
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
light yellow
solubility
DMSO: 10 mg/mL, clear, yellow
shipped in
ambient
Quality Level
General description
A blood-brain barrier-permeant indenopyrimidinone that acts as a dual A1/A2A antagonist (Ki = 48.2 and 6.5 nM, respectively, against agonist-induced cAMP response in A1- or A2A-expressing CHO-K1 cells) and effectively reverses D2 antagonist haloperidol- (1 mg/kg; s.c.) induced catalepsy in both rats and mice (ED50 = 0.3 and <0.1 mg/kg, respectively) in vivo by simultaneously reversing A1-mediated inhibition of DA (Dopamine) release and A2A-dependent inhibition of D2 receptor response to DA.
The Adenosine A2A/A₁ Receptor Antagonist controls the biological activity of Adenosine A2A/A₁ Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Shook, B.C., et al. 2012. J. Med. Chem.55, 1402.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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