质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
light yellow
溶解性
DMSO: 10 mg/mL, clear, yellow
运输
ambient
储存温度
2-8°C
SMILES字符串
NC(N=C1C2=CC=CC=C2)=NC(C3=C4C=CC(OCCN5CCOCC5)=C3)=C1C4=O
一般描述
A blood-brain barrier-permeant indenopyrimidinone that acts as a dual A1/A2A antagonist (Ki = 48.2 and 6.5 nM, respectively, against agonist-induced cAMP response in A1- or A2A-expressing CHO-K1 cells) and effectively reverses D2 antagonist haloperidol- (1 mg/kg; s.c.) induced catalepsy in both rats and mice (ED50 = 0.3 and <0.1 mg/kg, respectively) in vivo by simultaneously reversing A1-mediated inhibition of DA (Dopamine) release and A2A-dependent inhibition of D2 receptor response to DA.
The Adenosine A2A/A₁ Receptor Antagonist controls the biological activity of Adenosine A2A/A₁ Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications.
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Shook, B.C., et al. 2012. J. Med. Chem.55, 1402.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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