116814
Adenosine 3′,5′-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt
A cell-permeable and reversible inhibitor of protein kinase A (Ki = 11 µM).
别名:
Adenosine 3′,5′-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt, Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Rp, Rp-cAMPS, TEA, PKA Inhibitor V
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C10H11N5O5PS · 4C6H16N
化学文摘社编号:
分子量:
753.06
MDL编号:
UNSPSC代码:
41106305
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
crystalline solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
溶解性
water: 20 mg/mL
运输
wet ice
储存温度
−20°C
InChI
1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21-;/m1./s1
InChI key
OXIPZMKSNMRTIV-RNSTXJOVSA-N
一般描述
A cell-permeable and reversible inhibitor of protein kinase A (Ki = 11 µM). Resistant to hydrolysis by phosphodiesterases. Noncompetitive with respect to ATP.
Cell permeable inhibitor of protein kinase A (Ki = 11 µM). Resistant to hydrolysis by phosphodiesterases. Note: 5 µmol = 2.23 mg
Note: 5 µmol = 2.23 mg.
生化/生理作用
Cell permeable: yes
Primary Target
PKA
PKA
Product does not compete with ATP.
Reversible: yes
Target Ki: 11 µM against protein kinase A
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Van der Kloot, W., and Branisteanu, D.D. 1992. Eur. J. Phys.420, 336.
Yokozaki, H., et al. 1992. Cancer Res.52, 2504.
Butt, E., et al. 1990. FEBS Lett.263, 47.
Dostmann, W.R., et al. 1990. J. Biol. Chem.265, 10484.
Rothermel, J.D. 1988. Biochem. J. 251, 757.
Eckstein, F. 1985. Annu. Rev. Biochem.54, 367.
de Wit, R.J., et al. 1984. Eur. J. Biochem.142, 255.
O′Brian, C.A., et al. 1982. Biochemistry21, 4371.
Van der Kloot, W., and Branisteanu, D.D. 1992. Eur. J. Phys.420, 336.
Yokozaki, H., et al. 1992. Cancer Res.52, 2504.
Butt, E., et al. 1990. FEBS Lett.263, 47.
Dostmann, W.R., et al. 1990. J. Biol. Chem.265, 10484.
Rothermel, J.D. 1988. Biochem. J. 251, 757.
Eckstein, F. 1985. Annu. Rev. Biochem.54, 367.
de Wit, R.J., et al. 1984. Eur. J. Biochem.142, 255.
O′Brian, C.A., et al. 1982. Biochemistry21, 4371.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持