Quality Segment
ligand
(Trimethylammoniumethyl)
sterility
sterile (Caustic Stable)
product line
Eshmuno®
form
resin
specific analyte(s)
MAbs
parameter
1000 cm/hr flow rate, 1000 cm/hr max. flow rate, 8 bar max. pressure
matrix active group
polymer, polyvinyl ether
mean particle size
85 μm
capacity
150 mg binding capacity (BSA/mg of resin), ~150 mg, BSA binding capacity
transition temp
flash point 35 °C (own results)
density
1 g/cm3 at 20 °C
application(s)
recombinant protein
vaccine development
separation technique
anion exchange, mixed mode
storage temp.
2-30°C
General description
Eshmuno® Q resin is a strong anion exchange resin, coupling our renowned tentacle structure with a hydrophilic polyvinyl ether base matrix. Consequently, Eshmuno® Q resin offers outstanding results in typical anion exchange applications, such as removing biomolecules′ impurities in flow-through mode.
Features and Benefits
Eshmuno® Q chromatography resin enables:
Superior productivity for downstream processing of biomolecules
- Purification of acidic and neutral proteins and peptides from different sources, including plasma
Superior productivity for downstream processing of biomolecules
- High flow rate versus pressure-flow behavior
- Excellent removal of impurities, such as HCP, leached Protein A, and viruses
- Robust and safe packing procedures
- Strong chemical stability
Packaging
- 1.20079.0100: Eshmuno® Q Resin 100ml
- 1.20079.0010: Eshmuno® Q Resin 10ml
- 1.20079.0500: Eshmuno® Q Resin 500ml
- 1.20079.5000: Eshmuno® Q Resin 5L
Plastic bottle
Analysis Note
Appearance: Milky cream coloured turbid suspension, free from coarse mechanical impurities.
Microscopic evaluation: Spherical particles, no agglomerates, no fines.
Extractable matter (water): ≤ 0.08 %
Ionic capacity: 90 - 190 µeq/ml
Performance test (conalbumin): 9 - 19 mS/cm
Performance test (human serum albumin): 20 - 30 mS/cm
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 1.0 bar
Protein binding capacity(bovine serum albumin): 120 - 190 mg/ml
Particle size (50-120 µm): ≥ 80 %
Particle size (d50): 75 - 95 µm
Cerium: ≤ 30 µg/g
Endotoxins: ≤ 1.00 EU/ml
TAMC (total aerobic microbial count): ≤ 100 CFU/ml
TYMC (total yeast and mould count): ≤ 100 CFU/ml
Microscopic evaluation: Spherical particles, no agglomerates, no fines.
Extractable matter (water): ≤ 0.08 %
Ionic capacity: 90 - 190 µeq/ml
Performance test (conalbumin): 9 - 19 mS/cm
Performance test (human serum albumin): 20 - 30 mS/cm
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 1.0 bar
Protein binding capacity(bovine serum albumin): 120 - 190 mg/ml
Particle size (50-120 µm): ≥ 80 %
Particle size (d50): 75 - 95 µm
Cerium: ≤ 30 µg/g
Endotoxins: ≤ 1.00 EU/ml
TAMC (total aerobic microbial count): ≤ 100 CFU/ml
TYMC (total yeast and mould count): ≤ 100 CFU/ml
Legal Information
Eshmuno is a registered trademark of Merck KGaA, Darmstadt, Germany
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signalword
Warning
hcodes
Hazard Classifications
Flam. Liq. 3
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
95.0 °F
flash_point_c
35 °C
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