离子交换色谱树脂_ESHMUNO® IEX 色谱树脂-默克生命科学
离子交换 (IEX) 色谱是一种常用的纯化方法,它根据表面净电荷将目标分子与其他杂质分离开来。我们的阴离子交换 (AEX) 和阳离子交换 (CEX) 树脂组合以及多模式层析树脂可为 mAbs、疫苗、质粒 DNA、血浆和其他模式提供高效的纯化解决方案。
Products

这些树脂是高效下游纯化的理想选择,含有我们成熟的触手配体技术和刚性基质珠。它们可在快速流速下运行,并保持较高的结合能力,通过缩短时间和降低制造成本来提高生产率。
Eshmuno® CMX 混合模式树脂为 mAbs、融合蛋白和 ADC 的纯化以及低分子量杂质和 HCP 的分离提供了高选择性。
Eshmuno® CP-FT 树脂可在流过模式下高效去除 mAb 聚集物,与传统的结合/消光 CEX 色谱相比,负载能力提高了 10 倍。
Eshmuno® CPS 树脂可在盐浓度升高的情况下为重组蛋白原料流提供高动态结合能力和分离效率。这使得高电导率原料流(电导率≥10 mS/cm)的直接装载成为可能,从而减少了稀释的需要。
Eshmuno® CPX 树脂能有效地将 mAb 单体从聚集体和包括 HCP 在内的其他杂质中分离出来。
Eshmuno® HCX树脂可快速、高效地直接捕获蛋白质,在较高盐度下的典型离子交换和流通应用中表现出色。
Eshmuno® S 是一种强效 CEX 树脂,可直接捕获重组蛋白,并在捕获蛋白 A 后快速、高效地纯化 mAb。
Eshmuno® Q is a strong anion resin, providing superior dynamic binding capacity and outstanding impurity removal in typical anion exchange flow-through applications.
Fractogel® EMD IEX 色谱树脂
所有 Fractogel® EMD 树脂均具有高选择性和稳定的压力稳定性,可实现非常高的产量和卓越的产率。sup>® EMD 树脂具有高选择性和稳定的压力稳定性,可实现极高的通量和出色的收率。即使在高流速下,树脂的高结合能力也能节省宝贵的时间,提高工艺经济性。Fractogel® 树脂有不同尺寸的微珠和多种官能团,可满足各种纯化需求:
Fractogel®强阴离子交换剂
- Fractogel®EMD TMAE (S) 树脂
- Fractogel®EMD TMAE (M) 树脂
- Fractogel® EMD TMAE Hicap (M) 树脂
- Fractogel® EMD TMAE Medcap (M) 树脂
Fractogel® 弱阴离子交换剂
Fractogel®强阳离子交换剂
Fractogel®弱阳离子交换剂
相关资源
- Guide: Biochromatography Portfolio
Bulk Resin, Membranes and Prepacked Columns
- Guide: Chromatography Purification Selection
Protein A Affinity Chromatography Options
- Data Sheet: Eshmuno® CMX Resin
A highly selective mixed mode chromatography resin for difficult to purify mAbs, ADCs and fusion proteins
- Data Sheet: Eshmuno® CP‑FT Resin
A cation exchange resin specifically developed for the flow-through removal of aggregates using frontal chromatography
- Data Sheet: Eshmuno® CPS
High capacity and salt tolerance for recombinant protein purification
- Data Sheet: Eshmuno® CPX
Efficient impurity removal and strong binding capacity at high flow rates
- Data Sheet: Eshmuno® HCX Media
New, high salt-tolerant multi-mode chromatography resin
- Data Sheet: Eshmuno® S Resin for Superior Downstream mAB Purification
For superior downstream mAB purification
- Data Sheet: Eshmuno® Q Resin for Efficient AEX Chromatography
Eshmuno® Q resin is a strong anion exchange (AEX) resin, coupling our renowned tentacle structure with a hydrophilic polyvinyl ether base matrix
- Data Sheet: Fractogel® Chromatography Resin
Fractogel® resins consist of synthetic methacrylate based polymeric beads providing excellent pressure stability resulting in high flow rates
- Data Sheet: Robocolumn® and Minichrom Chromatography Columns
Small-scale prepacked chromatography columns for rapid process development, method optimization, parameter screening and sample preparation
- Article: Viral Clearance in Antibody Purification Using Tentacle Ion Exchangers
Manufacturers strive toward cost-effective purification of target molecules and a high level of confidence that their biologics are safe and not compromised by the presence of endogenous retrovirus-like particles or adventitious viruses.
- Article: Bioprocessing Technology Trends of RNA-based Therapeutics and Vaccines
This article reviews the current dynamics in the RNA therapeutics/vaccines market as well as differences between small-interfering RNA (siRNA), RNA interference (RNAi), microRNA (miRNA), and messenger RNA (MRNA).
- Article: RNA-Based Therapeutics and Vaccines
New Technologies Are Emerging to Overcome Challenges Associated with Toxicity and Drug Delivery.
- Application Note: ADC Separation Using a Mixed Mode Cation Exchange Chromatography Step in a mAb Process
The aim of this technical note is to provide a description of the steps followed and considerations taken during the development of antibody drug conjugate separation using a mixed mode cation exchange chromatography step.
- Application Note: Intensified Polishing Using Single-pass Tangential Flow Filtration (SPTFF) with Anion Exchange Chromatography
The bioprocessing industry is interested in Next Generation Processes with higher flexibility, lower costs, and higher product quality.
- Application Note: Eshmuno® CMX Application Note on Glycovariant Separation Including for COVID-19
The aim of this technical note is to provide a description of the capture and subsequent purification of glycoproteins.
- Tech Note: Development Strategy for a Cation Exchange (CEX) Chromatography Step in a Monoclonal Antibody (mAb) Process
The aim of this technical note is to provide a description of the steps followed and considerations taken during the development of a CEX chromatography step in a mAb process.
- Article: Purification of Extracellular Vesicles with Eshmuno® Q Resin and Natrix® Q Membrane
Separation and purification of subpopulations of extracellular vesicles (EVs) using Eshmuno® Q anion exchange resin and Natrix® Q membrane chromatography.
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