124020
Akt抑制剂X
The Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Akt抑制剂X, 10-（4ʹ-（N-二乙氨基）丁基）-2-氯吩恶嗪，HCl，10-NCP
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选择尺寸
关于此项目
经验公式（希尔记法）:
C20H25ClN2O · xHCl
化学文摘社编号:
分子量:
344.88 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
Akt抑制剂X, The Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
SMILES string
[Cl-].Clc1cc2c(cc1)Oc3c(cccc3)N2CCCC[N+H](CC)CC
InChI
1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
InChI key
SVKSJUIYYCQZEC-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
主靶
Akt
Akt
二级靶标
Rn细胞系（IC₅₀ = 2-5 µM）
Rn细胞系（IC₅₀ = 2-5 µM）
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：<5 µM 抗Akt；2-5 µM 抗Rh（横纹肌肉瘤）细胞系生长
Disclaimer
毒性：刺激性（B）
General description
Akt磷酸化及其体外激酶活性（完全抑制<5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 M), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H2O(Cat. No. 124039 ）的细胞可渗透性、可逆性和选择性抑制剂。
Other Notes
Tsvetkov, A.S., et al. 2010.Proc.Natl.Acad.Sci. USAin press.
Thimmaiah, K.N., et al. 2005.J. Biol. Chem.280, 31924.
Thimmaiah, K.N., et al. 2005.J. Biol. Chem.280, 31924.
Packaging
用惰性气体包装
Preparation Note
在复溶后分装并冻存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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