124020
Akt抑制剂X
The Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Akt抑制剂X, 10-(4ʹ-(N-二乙氨基)丁基)-2-氯吩恶嗪,HCl,10-NCP
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所有图片(1)
About This Item
经验公式(希尔记法):
C20H25ClN2O · xHCl
CAS Number:
分子量:
344.88 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
white
溶解性
water: 1 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[Cl-].Clc1cc2c(cc1)Oc3c(cccc3)N2CCCC[N+H](CC)CC
InChI
1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
InChI key
SVKSJUIYYCQZEC-UHFFFAOYSA-N
一般描述
Akt磷酸化及其体外激酶活性(完全抑制<5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 M), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H2O(Cat. No. 124039 )的细胞可渗透性、可逆性和选择性抑制剂。
生化/生理作用
主靶
Akt
Akt
二级靶标
Rn细胞系(IC₅₀ = 2-5 µM)
Rn细胞系(IC₅₀ = 2-5 µM)
产物不与ATP竞争。
可逆性:是
细胞可渗透性:是
靶标IC50:<5 µM 抗Akt;2-5 µM 抗Rh(横纹肌肉瘤)细胞系生长
包装
用惰性气体包装
警告
毒性:刺激性(B)
重悬
在复溶后分装并冻存(-20°C)。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Tsvetkov, A.S., et al. 2010.Proc.Natl.Acad.Sci. USAin press.
Thimmaiah, K.N., et al. 2005.J. Biol. Chem.280, 31924.
Thimmaiah, K.N., et al. 2005.J. Biol. Chem.280, 31924.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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