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124032

Akt Inhibitor XIV

Name: Akt Inhibitor XIV
Brand: MM

The Akt Inhibitor XIV, also referenced under CAS 1191951-57-1, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

Akt Inhibitor XIV, 4-Dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide, PDK1 Inhibitor III, PHT-427

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₁N₃O₂S₂

化学文摘社编号:

1191951-57-1

分子量:

409.61

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze

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属性

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C20H31N3O2S2/c1-2-3-4-5-6-7-8-9-10-11-12-18-13-15-19(16-14-18)27(24,25)23-20-22-21-17-26-20/h13-17H,2-12H2,1H3,(H,22,23)

InChI key

BYWWNRBKPCPJMG-UHFFFAOYSA-N

说明

General description

A cell-permeable thiadiazolyl compound that binds to PH (pleckstrin homology) domain (K_d = 40.8 µM, K_i = 2.4 µM) and acts as a competitive and reversible blocker of Akt translocation to the cellular membrane with selectivity over PDK1 (K_d = 90.1 µM, K_i = 5.5 µM). Inhibits pAkt-Ser⁴⁷³ (IC₅₀ = 6.3, 8.6 and 10 µM in Panc-1, BxPC-3 and MiaPaCa-2 cells, respectively), and induces apoptosis at 20 µM (40% and 31%) and causes growth arrest (IC₅₀ = 65 and 30 µM) in Panc-1 and MiaPaCa-2 cells, respectively. Further, suppresses tumor growth and regression in mouse xenograft model (125 mg/kg, i.p.) and reduces pGSK-3α-Ser²¹ and pGSK-3β-Ser⁹ and p70S6K-Thr³⁸⁹ levels.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Meuillet, E.J., et al. 2010. Mol. Cancer Ther. 9, 706.
Moses, S.A., et al. 2009. Cancer Res. 69, 5073.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c