方案
≥90% (by absorbance)
表单
lyophilized solid
颜色
white
溶解性
H2O: 10 mg/mL
methanol: soluble
一般描述
α-Amanitin, Amanita sp. is a toxic bicyclic octapeptide isolated from mushrooms. A potent & specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes.
Toxic bicyclic octapeptide isolated from mushrooms. Acts as a potent and specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes, including animals and plants.
生化/生理作用
RNA polymerase 2
制备说明
Reconstitute to a concentration ≥1 mM
警示用语：
Danger
危险声明
危险分类
Acute Tox. 1 Oral - STOT RE 2
靶器官
Kidney,Blood,Liver,Gastrointestinal tract,Respiratory Tract,Central nervous system
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
法规信息
新产品
此项目有
C Scheurlen et al.
Zeitschrift fur Gastroenterologie, 32(7), 399-404 (1994-07-01)
Alpha-amanitin, the main toxin of the death cap fungus (Amanita phalloides) is one of the most dangerous natural poison. This toxin damages eukaryotic cells by inhibiting their transcription. Lesions are seen in cells with rapid protein synthesis, particular in liver
A Tamin et al.
Virology, 182(1), 393-396 (1991-05-01)
The locus responsible for encoding resistance to alpha-amanitin was previously mapped to the vaccinia virus (VV) HindIII N fragment by using cloned wild-type VV DNA fragments to rescue the ability of an alpha-amanitin-resistant/temperature-sensitive VV mutant (alpha rts7) to replicate under
P M Kastrop et al.
Molecular reproduction and development, 28(3), 249-254 (1991-03-01)
Bovine cumulus oocyte complexes were cultured for various periods and either denuded and orcein stained or radiolabeled with 35S-methionine or 32P-orthophosphate. Specific inhibitors were added to the culture medium to investigate mRNA and protein synthesis requirements for both nuclear and
K Baumann et al.
Protein science : a publication of the Protein Society, 3(5), 750-756 (1994-05-01)
Four amatoxin-binding proteins with KD values in the nanomolar range, 3 monoclonal antibodies and RNA polymerase II, were studied with respect to their affinities to 24 alpha-amanitin derivatives with modified side chains. From KD values we estimated the amounts of
T Wieland
International journal of peptide and protein research, 22(3), 257-276 (1983-09-01)
The results of 50 years of effort in the chemistry of Amanita toxins are reviewed. The phallotoxins, fast acting components, but not responsible for fatal intoxications after ingestion, are bicyclic heptapeptides. They combine with F-actin, stabilizing this protein against several
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