129875
Amastatin, Streptomyces sp. - CAS 67655-94-1 - Calbiochem
Amastatin is a non-toxic inhibitor of aminopeptidase A (Ki = 1 µM) and leucine aminopeptidase.
别名:
Amastatin, Streptomyces sp. - CAS 67655-94-1 - Calbiochem, (2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp-OH
InChI key
QFAADIRHLBXJJS-ZAZJUGBXSA-N
InChI
1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
assay
≥97% (HPLC)
form
amorphous solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
colorless
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
10-30°C
Quality Level
General description
Non-toxic inhibitor of aminopeptidase A (Ki = 1 µM) and leucine aminopeptidase. Also acts as a slow-binding, competitive inhibitor of aminopeptidase M. Does not inhibit aminopeptidase B, chymotrypsin, elastase, papain, pepsin, thermolysin, or trypsin.
Non-toxic specific inhibitor of aminopeptidase A and leucine aminopeptidase. Also acts as a slow-binding, competitive inhibitor of aminopeptidase M. Does not inhibit aminopeptidase B, chymotrypsin, elastase, papain, pepsin, thermolysin, or trypsin.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Aminopeptidase A
Aminopeptidase A
Product does not compete with ATP.
Reversible: no
Target Ki: 1 µM against aminopeptidase A
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Rich, D.H., et al. 1984. J. Med. Chem. 27, 417.
Jobe, H., et al. 1979. Agric. Biol. Chem.43, 591.
Aoyagi, T., et al. 1978. J. Antibiot.31, 636.
Jobe, H., et al. 1979. Agric. Biol. Chem.43, 591.
Aoyagi, T., et al. 1978. J. Antibiot.31, 636.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13
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