Core Histones

Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin. Some histones function as spools for the thread-like DNA to wrap around forming a nucleosome. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, where additional H1 histone proteins are associated with each nucleosome to maintain the chromosome structure.

Core histones and histone H1, purified from chicken erythrocytes; suitable as a substrate for HAT assays; purity = 90%

Lyophilized

Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -70°C

rountinely evaluated by immunoblot using Anti-Histone H3 (05-499) and Anti-Histone H4 (07-108)

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