生物来源
human
质量水平
重组
expressed in baculovirus infected Sf21 cells
分子量
Mw 59 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
UniProt登记号
运输
dry ice
一般描述
N末端带有His6标签的重组全长人Akt1
分析说明
通过Crosstide 的磷酸化进行常规评估。
其他说明
比活相关数据，请参阅检验报告以获取该酶的单独批次。
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
储存分类代码
10 - Combustible liquids
WGK
WGK 2
Dos D Sarbassov et al.
Molecular cell, 22(2), 159-168 (2006-04-11)
The drug rapamycin has important uses in oncology, cardiology, and transplantation medicine, but its clinically relevant molecular effects are not understood. When bound to FKBP12, rapamycin interacts with and inhibits the kinase activity of a multiprotein complex composed of mTOR
Chia-Chen Chen et al.
Developmental cell, 18(4), 592-604 (2010-04-24)
FoxO transcription factors and TORC1 are conserved downstream effectors of Akt. Here, we unraveled regulatory circuits underlying the interplay between Akt, FoxO, and mTOR. Activated FoxO1 inhibits mTORC1 by TSC2-dependent and TSC2-independent mechanisms. First, FoxO1 induces Sestrin3 (Sesn3) gene expression.
Han C Dan et al.
Oncotarget, 7(16), 21064-21075 (2016-03-31)
The ser-thr Akt plays a critical role in the regulation of cell survival, cell growth and proliferation, as well as energy metabolism and is dysregulated in many cancers. The regulation of Akt activity depends on the phosphorylation at two sites:
Chang Hwa Jung et al.
Autophagy, 7(10), 1212-1221 (2011-07-29)
ULK1 (Unc51-like kinase, hATG1) is a Ser/Thr kinase that plays a key role in inducing autophagy in response to starvation. ULK1 is phosphorylated and negatively regulated by the mammalian target of rapamycin complex 1 (mTORC1). Previous studies have shown that
K Shanmugasundaram et al.
Oncogene, 32(16), 2027-2036 (2012-06-27)
The cyclin-dependent kinase inhibitor p27 is a key regulator of cell-cycle progression. Its expression and localization are altered in several types of malignancies, which has prognostic significance in cancers such as renal cell carcinoma (RCC). S-phase kinase-associated protein 2 (SKP-2)
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