ABL (T315I) Protein, active

N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation

Contains the gatekeeper mutation T315I in the ATP-binding domain. This mutation decreases the sensitivity to Gleevec by more than 200-fold as compared to the wild type sequence.

Product Source: Expressed by baculovirus in Sf21 insect cells

Research Category
Metabolism

Inflammation & Immunology

Research Sub Category
Obesity

Metabolic Disorders

Osteoporosis

Arthritis

Protein Target: Abl

Target Sub-Family: TK

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-522M when ordering the 250 µg size.

Ni²⁺/NTA-agarose

6 months at -70°C

routinely evaluated by phosphorylation of Abltide

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.