产品名称
PP1α 蛋白,10 µg, Recombinant, full length, human PP1α, for use in Phosphatase Assays.
biological source
human
recombinant
expressed in E. coli
form
solution
shelf life
6 mo.
mol wt
Mw 37.6 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (phosphatase)
solubility
water: soluble
NCBI accession no.
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... PPP1CA(5499)
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Analysis Note
通过100μM DiFMUP的去磷酸化进行常规评估
Application
研究类别
炎症 & 免疫学
炎症 & 免疫学
Biochem/physiol Actions
蛋白质靶标:PP1α亚家族靶标:丝氨酸/半胱氨酸磷酸酶
蛋白磷酸酶 1(PP1)与多种生物过程有关,包括突触可塑性、细胞周期进展、多巴胺能神经传递、收缩和糖代谢、维持微管稳定性和tau的去磷酸化。此外,PP-1在突触发育、可塑性、信号传导、神经元生长、突触形成、离子通道功能和神经传导等方面也发挥着重要作用。树突棘内PP-1信号的变化与各种神经和精神疾病有关。
蛋白磷酸酶 1(PP1)与多种生物过程有关,包括突触可塑性、细胞周期进展、多巴胺能神经传递、收缩和糖代谢、维持微管稳定性和tau的去磷酸化。此外,PP-1在突触发育、可塑性、信号传导、神经元生长、突触形成、离子通道功能和神经传导等方面也发挥着重要作用。树突棘内PP-1信号的变化与各种神经和精神疾病有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
研究领域:神经科学
蛋白磷酸酶 1(PP1)是重要的丝氨酸/苏氨酸特异性蛋白磷酸酶之一。
蛋白磷酸酶 1(PP1)是重要的丝氨酸/苏氨酸特异性蛋白磷酸酶之一。
Other Notes
关于比活相关数据,请参阅该酶单独批次的检验报告。
Packaging
也提供250 µg的规格-订购250 µg的规格时,请致电咨询价格和供货情况,参考目录号14-595M。
Physical form
肝素琼脂糖,然后是Q琼脂糖
Preparation Note
自发货之日起可在-20°C保存6个月
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
Karl Foley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(14), 3040-3050 (2021-04-09)
Protein phosphatases, by counteracting protein kinases, regulate the reversible phosphorylation of many substrates involved in synaptic plasticity, a cellular model for learning and memory. A prominent phosphatase regulating synaptic plasticity and neurologic disorders is the serine/threonine protein phosphatase 1 (PP1).
Targeting phosphatases as the next generation of disease modifying therapeutics for Parkinson?s disease
Braithwaite SP, et al.
Neurochemistry International, 61, 899-906 (2012)
The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity.
Munton, Richard P, et al.
Febs Letters, 567, 121-128 (2004)
Modulation of dendritic spines by protein phosphatase-1
Advances in Pharmacology, 90.0, 117-144 (2021)
Alphonse Garcia et al.
Biochimie, 85(8), 721-726 (2003-10-31)
The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of
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