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14-787-M

PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.

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UNSPSC Code:
12352200
NACRES:
NA.32
eCl@ss:
32160405
Biological source:
mouse
Recombinant:
expressed in baculovirus infected Sf21 cells
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biological source

mouse

Quality Level

100, 300

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

Mw 129 kDa (p110α; H1047R), Mw 83.6 kDa (p85α)

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_006218.2

UniProt accession no.

P42336

Gene Information

mouse ... PIK3CA(18706)

General description

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R αand untagged, recombinant, full length mouse p85α.
Product Source: Coexpressed by baculovirus in Sf21 insect cells.
The H1047R substitution in p110α is associated with a number of human cancers. The residue is conserved between the human and mouse sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type, and is able to induce oncogenic transformation.

Application

Research Category
Inflammation & Immunology

Biochem/physiol Actions

Protein Target: PI3Kα/p85α
Target Sub-Family: PI3K/PI4K

Packaging

Also available in 250μg size --call for pricing and availability and reference catalog number 14-787M when ordering the 250μg size.

Physical form

Ni2+/NTA-agarose

Preparation Note

Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

存储类别

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Unlocking the Mystery of Cancer: Do the Mutant p110α Subunits of PI3-Kinase Hold the Key?

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High frequency of mutations of the PIK3CA gene in human cancers.
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全球贸易项目编号

货号GTIN
14-78704053252475931
14-787M04053252734182