16-319
Anti-Rac1 Antibody, clone 23A8, Magnetic bead Conjugate
purified antibody, clone 23A8, from mouse
别名:
Cell migration-inducing gene 5 protein, Ras-like protein TC25, migration-inducing gene 5, migration-inducing protein 5, ras-related C3 botulinum toxin substrate 1, ras-related C3 botulinum toxin substrate 1 (rho family,small GTP binding protein Rac1), ra
产品名称
Anti-Rac1 Antibody, clone 23A8, Magnetic bead Conjugate, purified antibody, clone 23A8, from mouse
biological source
mouse
conjugate
magnetic beads conjugate
antibody form
purified antibody
antibody product type
primary antibodies
clone
23A8, monoclonal
species reactivity
human, rat, mouse
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RAC1(5879)
Application
Anti-Rac1 Antibody, clone 23A8, Magnetic bead Conjugate detects level of Rac1 & has been published & validated for use in WB & IP.
Biochem/physiol Actions
Other species have not been tested.
Recognizes human Rac1.
General description
Rac1 is a member of a RhoGTPase subfamily (Rac1-Rac4) that transduces extracellular signals from G-coupled protein receptors (GPCR), integrins and growth factor receptors to effector molecules that modulate multiple signaling pathways. While Rac1 supports the activation of MAPkinase pathways and gene activation, it’s most important functions include the regulation of cytoskeletal structures. Together with Rho (regulator of stress fibers) and Cdc42 (regulator of filopodia), Rac modulates the formation of focal adhesion (FA) complexes; membrane ruffles and lamellipodia that contribute to important cell functions related to cell attachment and movement.
21 kDa
Preparation Note
Stable for 1 year at 2-8°C from date of receipt. DO NOT FREEZE! Wash the magnetic beads with an appropriate buffer prior to use to remove sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 2
Mian Zhou et al.
Cellular & molecular immunology, 20(1), 80-93 (2022-12-06)
In sepsis, macrophage bacterial phagocytosis is impaired, but the mechanism is not well elucidated. Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern that causes inflammation. However, whether eCIRP regulates macrophage bacterial phagocytosis is unknown. Here, we reported that
Armin Bayati et al.
Cell reports, 40(3), 111102-111102 (2022-07-21)
The nervous system spread of alpha-synuclein fibrils is thought to cause Parkinson's disease (PD) and other synucleinopathies; however, the mechanisms underlying internalization and cellular spread are enigmatic. Here, we use confocal and superresolution microscopy, subcellular fractionation, and electron microscopy (EM)
Zihang Chen et al.
The Journal of physiology, 598(12), 2415-2430 (2020-04-03)
Spinal cord dorsal horn srGAP3 (slit-robo GTPase activating protein 3) increases in the initiation phase of neuropathic pain and decreases in the maintenance phase. However, Rac1 activity, which can be reduced by srGAP3, decreases in the initiation phase and increases
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