生物来源
rabbit
质量水平
抗体形式
serum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
liquid
种属反应性
human
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
dilution
(Immunoblotting (1:5000-1:20,000)
Immunofluorescence (1:1000)
Immunohistochemistry (1:1000)
Immunoprecipitation (1:1000))
同位素/亚型
IgG
运输
ambient
储存温度
−20°C
靶向翻译后修饰
unmodified
一般描述
兔多克隆抗体以未稀释的血清形式提供。识别全长APP和C端可溶性产物CTFγ（~6 kDa）、CTFα（~9 kDa）和CTFβ（~11 kDa）。
兔多克隆抗淀粉样蛋白前体蛋白C末端（751-770）可识别全长APP和C末端可溶性产物CTFα，β和γ。经验证可用于WB、IF、IHC和IP。
识别全长APP和C端可溶性产物CTFγ（~6 kDa）、CTFα（~9 kDa）和CTFβ（~11 kDa）。抗体靶基因符号：APP 靶标异名：AAA，AD1，Adap，AL024401，淀粉样蛋白前体，淀粉样蛋白糖蛋白，APP异构体1，APPI，appican，CTFgamma，CVAP，E030013M08RIK，Nexin II，P3，PN2，PreA4，蛋白酶 NEXIN2 Entrez基因名称：淀粉样β（A4）前体蛋白 Hu Entrez ID：351（相关抗体：PC729, PC152,PC151, PC150, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537) Mu Entrez ID: 11820 大鼠Entrez ID：54226
免疫原
人
合成肽[(C)KMQQNGYENPTYKFFEQMQN]，对应于人前体蛋白（APP）的751-770位氨基酸，与KLH偶联
应用
免疫印迹（1:5000-1:20,000）
免疫荧光（1:1000）
免疫组织化学（1:1000）
免疫沉淀（1:1000）
免疫荧光（1:1000）
免疫组织化学（1:1000）
免疫沉淀（1:1000）
制备说明
初次融化后，等分并冷冻（-20°C）。
其他说明
Pinnix, I., et al. 2001.J. Biol. Chem.276, 481.
合适的工作稀释度由与测定条件相关的变量决定。
法律信息
采购本材料仅供研究使用。在将0433抗体或任何衍生物用于临床诊断或治疗目的之前，请用户向Mayo索取许可证。有关许可信息，请联系：Mayo Medical Ventures，技术商业化办公室（507）284-8878，200 First Street SW，Rochester，MN 55905-001。
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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The EMBO journal, 38(17), e101064-e101064 (2019-07-31)
Alzheimer's disease is the most prevalent type of dementia and is caused by the deposition of extracellular amyloid-beta and abnormal tau phosphorylation. Neuroinflammation has emerged as an additional pathological component. Microglia, representing the brain's major innate immune cells, play an
Vincent J Mecozzi et al.
Nature chemical biology, 10(6), 443-449 (2014-04-22)
Retromer is a multiprotein complex that trafficks cargo out of endosomes. The neuronal retromer traffics the amyloid-precursor protein (APP) away from endosomes, a site where APP is cleaved into pathogenic fragments in Alzheimer's disease. Here we determined whether pharmacological chaperones
Yang Xiang et al.
Acta neuropathologica, 130(4), 487-499 (2015-09-14)
Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). The physiological capacity of peripheral tissues and organs in clearing brain-derived Aβ and its therapeutic potential for AD remains largely unknown. Here, we measured blood Aβ levels
Jenna C Carroll et al.
Brain research, 1366, 233-245 (2010-10-12)
The risk of Alzheimer's disease (AD) is higher in women than in men, a sex difference that likely results from the effects of sex steroid hormones. To investigate this relationship, we first compared progression of β-amyloid (Aβ) pathology in male
Giselle P Lim et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(12), 3032-3040 (2005-03-25)
Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of Alzheimer's disease (AD). DHA levels are lower in serum and brains of AD patients, which could result
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