172060
Andrographolide
A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties.
别名:
Andrographolide, Andro
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关于此项目
经验公式（希尔记法）:
C20H30O5
化学文摘社编号:
分子量:
350.45
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
O1CC(\C(=C/C[C@H]2[C@]3(C(C(C(CC3)O)(CO)C)CCC2=C)C)\C1=O)O
InChI
1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15?,16?,17?,19+,20?/m1/s1
InChI key
BOJKULTULYSRAS-ZJFCSBQFSA-N
description
Merck USA index - 14, 633
assay
≥95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
chloroform: methanol (1:1): 10 mg/mL, DMSO: 15 mg/mL (Use only fresh DMSO.)
shipped in
ambient
Quality Level
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General description
A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
An irreversible blocker of NF-κB and AP-1 (IC50 ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.
Biochem/physiol Actions
Cell permeable: no
Primary Target
NF-κB and AP-1 activation
NF-κB and AP-1 activation
Product does not compete with ATP.
Reversible: no
Target IC50: ≤ 15 µM against NF-κB and AP-1 activation
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Xia, Y.F., et al. 2004. J. Immunol.173, 4207.
Chen, J.H., et al. 2004. Biochem. Pharmacol.67, 1337.
Yu, B.C., et al. 2003. Planta Med.69, 1075.
Chen, J.H., et al. 2004. Biochem. Pharmacol.67, 1337.
Yu, B.C., et al. 2003. Planta Med.69, 1075.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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