176880
茴香霉素，来源于浅灰链霉菌
Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells.
别名:
茴香霉素，来源于浅灰链霉菌, 2-（p-甲氧基苄基）-3,4-吡咯烷二醇-3-乙酸酯
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关于此项目
经验公式（希尔记法）:
C14H19NO4
化学文摘社编号:
分子量:
265.30
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 100 mg/mL, methanol: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m0/s1
InChI key
YKJYKKNCCRKFSL-BFHYXJOUSA-N
General description
强烈激活哺乳动物细胞中的应激激活蛋白激酶（JNK/SAPK）和p38 MAP激酶。与生长因子协同作用，通过充当有效的信号激动剂来诱导c-fos和c-jun。一种在翻译步骤蛋白合成的抑制剂。也已知在人单核细胞系U937中诱导凋亡。
激活p54和MAP激酶。参与应激激活蛋白激酶（SAPKs）的激活。与生长因子协同作用，通过充当有效的信号激动剂来诱导c-fos和c-jun。一种在翻译步骤蛋白合成的抑制剂。也已知在人单核细胞系U937中诱导凋亡。
Preparation Note
复溶后，储存在冰箱中（4°C）。DMSO储备液可在4°C下稳定保存6个月。
Other Notes
Hazzalin, C.A., et al. 1998.Mol.Cell.Biol. 18, 1844.
Kardalinou, E., et al. 1994.Mol.Cell.Biol.14, 1066.
Kyriakis, J.M., et al. 1994.Nature 369, 156.
Sanchez, I., et al. 1994.Nature 372, 794.
Shinohara, K., and Oka, T. 1994.NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J.1993.Exp.Cell Res.208, 296.
Kardalinou, E., et al. 1994.Mol.Cell.Biol.14, 1066.
Kyriakis, J.M., et al. 1994.Nature 369, 156.
Sanchez, I., et al. 1994.Nature 372, 794.
Shinohara, K., and Oka, T. 1994.NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J.1993.Exp.Cell Res.208, 296.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有毒（F）
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 176880-10MG | 04055977223002 |