178220
Antipain, Hydrochloride
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.
别名:
Antipain, Hydrochloride
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关于此项目
经验公式（希尔记法）:
C27H44N10O6 · xHCl
化学文摘社编号:
分子量:
604.70 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
SMILES string
[Cl-].[Cl-].N([C@@H](C(C)C)C(=O)NC(=O)[C@@H](NC(=O)NC(Cc1ccccc1)C(=O)O)CCCN=C(N)N)C(CCCN=C(N)N)C=O.[H+].[H+]
InChI
1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1
InChI key
GXQPAKIVOCLCHD-BXLPLHKWSA-N
description
RTECS - YV9350800
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white to slightly yellowish
solubility
water: 10 mg/mL
shipped in
ambient
Quality Level
General description
Effective concentration: 1-100 µM.
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975 ). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Trypsin-like serine proteases
Trypsin-like serine proteases
Product does not compete with ATP.
Reversible: no
Target IC50: 300 µM against trypsin-like serine proteases, papain and some cysteine proteases
Preparation Note
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Other Notes
Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Umezawa, H. 1976. Methods Enzymol.55, 678.
Umezawa, H. 1976. Methods Enzymol.55, 678.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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