ASB-C8Ø

A zwitterionic detergent (zwittergent^®) containing an aromatic core that has been demonstrated to stabilize and solubilize integral membrane proteins by breaking aggregates. Useful for protein analysis and characterization by two-dimensional gel electrophoresis and mass spectrometry techniques. Reported to be superior to CHAPS (Cat. No. 220201) in solubilizing an ion-channel protein and a G-protein coupled receptor (GPCR). In combination with thiourea and urea, also reported to improve the recovery of hydrophobic proteins from Arabidopsis thaliana.

A zwitterionic detergent with an aromatic core that is shown to stabilize and solubilize integral membrane proteins by breaking aggregates. Useful for protein analysis and characterization by two-dimensional (2-D) gel electrophoresis and mass spectrometry techniques. Reported to be superior to CHAPS (Cat. No. 220201 ) in solubilizing both an anion-channel and a G-protein coupled receptor (GPCR).

Packaged under inert gas

Following reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Henningsen, R., et al. 2002. Proteomics2, 1479.
Molloy, M.P. 2000. Anal. Biochem.280, 1.
Santoni, V., et al. 2000. Electrophoresis21, 3329.
Rabilloud, T., et al. 1999. Electrophoresis20, 3603.
Santoni, V., et al. 1999. Electrophoresis20, 705.
Herbert, B. 1999. Electrophoresis20, 660.
Chevallet, M., et al. 1998. Electrophoresis19, 1901.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Zwittergent is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Irritant (B)