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Merck
CN

189291

Sigma-Aldrich

Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem

A cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver microsomes).

别名:

Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem, (3 R,5 R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,, (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,

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关于此项目

线性分子式:
[(C33H34FN2O5)2Ca · 3H2O]1/2
化学文摘社编号:
134523-03-8
UNSPSC代码:
12352200

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质量水平

100

方案

≥97% (HPLC)

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

颜色

white

溶解性

methanol: 10 mg/mL, clear, colorless
DMSO: 100 mg/mL, clear, colorless
ethanol: 2 mg/mL, clear, colorless
water: insoluble

运输

ambient

储存温度

2-8°C

InChI

1S/2C33H35FN2O5.Ca/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);/q;;+2/p-2/t2*26-,27-;/m11./s1

InChI key

FQCKMBLVYCEXJB-MNSAWQCASA-L

一般描述

A cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver microsomes). Reduces cholesterol synthesis and increases the expression LDL receptors in hepatocytes. Exhibits anti-inflammatory and anti-oxidant properties. Acts as a hypotensive agent that acts by enhancing flow mediated dilation. Shown to overcome carboplatin resistance in non-small-cell lung carcinomas possibly by suppressing Akt activity and upregulating TIMP-1.

包装

Packaged under inert gas

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Chen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
Tycinska, A.M., et al. 2011. Arch. Med. Sci.7, 955.
Law, M.R., et al. 2003. BMJ326, 1423.

Youssef, S., et al. 2002. Nature420, 78.
Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol.18, 1906.

Bustos, C., et al. 1998. J. Am. Coll. Cardiol.32, 2057.
Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta1123, 133.
Roth, B.D., et al. 1991. J. Med. Chem.34, 463.
Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun.170, 726.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

10-13 - German Storage Class 10 to 13

法规信息

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